PF-6683324
Based on 1 Customer Validation
PF-6683324 (Trk-IN-4) is a potent pan-Trk inhibitor in cell-based assays with IC50s of 1.9 nM, 2.6 nM and 1.1 nM for TrkA, TrkB and TrkC, respectively. Anti-hyperalgesic effect.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.41%
- CAS 番号: 1799788-94-5
- 分子式: C24H23F4N5O4
- 分子量:521.46
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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TrkA 1.9 nM (IC50, in cell-based assays) |
TrkB 2.6 nM (IC50, in cell-based assays) |
TrkC 1.1 nM (IC50, in cell-based assays) |
PF-6683324 (Trk-IN-4) (Compound 10b) exhibits superb Trk selectivity with >95% inhibition of TrkA and >40% inhibition of only 1 other kinase VEGFR2 (cell-based assay for VEGFR2 IC50>5 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1799788-94-5
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性状 Solid
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分子量 521.46
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分子式 C24H23F4N5O4
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Color Off-white to light yellow
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SMILES
O=C(N)C1=C(O[C@H]2CCN(C(CC3=CC=C(OC(F)(F)F)C=C3)=O)C[C@H]2F)N=CC(C4=CN(C)C=N4)=C1
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別名
Trk-IN-4
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : ≥ 100 mg/mL (191.77 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9177 mL | 9.5885 mL | 19.1769 mL | 47.9423 mL |
| 5 mM | 0.3835 mL | 1.9177 mL | 3.8354 mL | 9.5885 mL | |
| 10 mM | 0.1918 mL | 0.9588 mL | 1.9177 mL | 4.7942 mL | |
| 15 mM | 0.1278 mL | 0.6392 mL | 1.2785 mL | 3.1962 mL | |
| 20 mM | 0.0959 mL | 0.4794 mL | 0.9588 mL | 2.3971 mL | |
| 25 mM | 0.0767 mL | 0.3835 mL | 0.7671 mL | 1.9177 mL | |
| 30 mM | 0.0639 mL | 0.3196 mL | 0.6392 mL | 1.5981 mL | |
| 40 mM | 0.0479 mL | 0.2397 mL | 0.4794 mL | 1.1986 mL | |
| 50 mM | 0.0384 mL | 0.1918 mL | 0.3835 mL | 0.9588 mL | |
| 60 mM | 0.0320 mL | 0.1598 mL | 0.3196 mL | 0.7990 mL | |
| 80 mM | 0.0240 mL | 0.1199 mL | 0.2397 mL | 0.5993 mL | |
| 100 mM | 0.0192 mL | 0.0959 mL | 0.1918 mL | 0.4794 mL |
PF-6683324 関連分類
HY-112436 関連分類
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