PG-931
Based on 1 Customer Validation
PG-931, an analog of SHU 9119 (HY-P0227), is a potent melanocortin 4 (MC4) receptor (IC50=0.58 nM) agonist and is more selective than for the hMC3R (IC50=55 nM) or the hMC5R (IC50=2.4 nM). PG-931 can reverse haemorrhagic shock and prevent multiple organ damage in vivo.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.60%
- CAS 番号: 667430-81-1
- 分子式: C59H85N15O11
- 分子量:1180.40
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保管条件:
Sealed storage, away from moisture and light, under nitrogen.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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MC4R |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar rats[2]
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Dosage:13-108 nmol/kg
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Administration:Intravenous injection; single dose
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Result:Exhibitd an anti-shock effect occurred at nanomolar doses.
化学情報
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CAS 番号 667430-81-1
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性状 Solid
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分子量 1180.40
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分子式 C59H85N15O11
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Color White to off-white
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配列
Ac-{Nle}-Asp-Pro-{d-Phe}-Arg-Trp-Lys-Pro-Val-NH2 (Lactam bridge: Asp2-Lys7)
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シーケンスの短縮
Ac-{Nle}-DP-{d-Phe}-RWKPV-NH2 (Lactam bridge: Asp2-Lys7)
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture and light, under nitrogen
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
溶剤 & 溶解度
H2O : 100 mg/mL (84.72 mM; Need ultrasonic)
DMSO : ≥ 100 mg/mL (84.72 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (283 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. D Giuliani, et al. Selective melanocortin MC4 receptor agonists reverse haemorrhagic shock and prevent multiple organ damage. Br J Pharmacol [Content Brief]
[2]. P Grieco, et al. Extensive structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5. J Pept Res [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 0.8472 mL | 4.2359 mL | 8.4717 mL | 21.1793 mL |
| 5 mM | 0.1694 mL | 0.8472 mL | 1.6943 mL | 4.2359 mL | |
| 10 mM | 0.0847 mL | 0.4236 mL | 0.8472 mL | 2.1179 mL | |
| 15 mM | 0.0565 mL | 0.2824 mL | 0.5648 mL | 1.4120 mL | |
| 20 mM | 0.0424 mL | 0.2118 mL | 0.4236 mL | 1.0590 mL | |
| 25 mM | 0.0339 mL | 0.1694 mL | 0.3389 mL | 0.8472 mL | |
| 30 mM | 0.0282 mL | 0.1412 mL | 0.2824 mL | 0.7060 mL | |
| 40 mM | 0.0212 mL | 0.1059 mL | 0.2118 mL | 0.5295 mL | |
| 50 mM | 0.0169 mL | 0.0847 mL | 0.1694 mL | 0.4236 mL | |
| 60 mM | 0.0141 mL | 0.0706 mL | 0.1412 mL | 0.3530 mL | |
| 80 mM | 0.0106 mL | 0.0529 mL | 0.1059 mL | 0.2647 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
PG-931 関連分類
HY-P1208 関連分類
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