Pheophorbide A
Based on 2 publication(s) in Google Scholar
Pheophorbide A is an intermediate product in the chlorophyll degradation pathway. Pheophorbide A can be used as a photosensitizer. Pheophorbide A is a lymphatic vascular activator. Pheophorbide A has antitumor activity. Pheophorbide A can be used for human lymphatic vascular insufficiencies research.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.20%
- CAS 番号: 15664-29-6
- 分子式: C35H36N4O5
- 分子量:592.68
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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MedChemExpress（MCE）の使用を引用している文献 Pheophorbide A
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| 1A9 | ED50 |
0.48 μg/mL
Compound: 2
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Cytotoxicity against human 1A9 cells after 72 hrs by SRB assay
Cytotoxicity against human 1A9 cells after 72 hrs by SRB assay
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[PMID: 11473423] |
| A549 | ED50 |
1.5 μg/mL
Compound: 2
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Cytotoxicity against human A549 cells after 72 hrs by SRB assay
Cytotoxicity against human A549 cells after 72 hrs by SRB assay
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[PMID: 11473423] |
| HCT-8 | ED50 |
1.5 μg/mL
Compound: 2
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Cytotoxicity against human HCT8 cells after 72 hrs by SRB assay
Cytotoxicity against human HCT8 cells after 72 hrs by SRB assay
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[PMID: 11473423] |
| KB | ED50 |
0.46 μg/mL
Compound: 2
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Cytotoxicity against human KB cells after 72 hrs by SRB assay
Cytotoxicity against human KB cells after 72 hrs by SRB assay
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[PMID: 11473423] |
| MCF7 | ED50 |
1.6 μg/mL
Compound: 2
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Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay
Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay
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[PMID: 11473423] |
| SK-MEL | ED50 |
0.91 μg/mL
Compound: 2
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Cytotoxicity against human SK-MEL cells after 72 hrs by SRB assay
Cytotoxicity against human SK-MEL cells after 72 hrs by SRB assay
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[PMID: 11473423] |
Pheophorbide A (10 µM) increases lymphatic endothelial cells (LECs) sprouting, proliferation and tube formation[1].
Pheophorbide A-mediated photodynamic therapy (Pa-PDT) inhibits cellular growth on Hep3B, in a dose-dependent manner with an IC50 of 1.5 μM[2].
Pheophorbide A (2 µM, 24 h) induces apoptosis in Hep3B cells after photo-activation[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male immunocompetent C3H mouse (six-week-old, inoculated subcutaneously with AT-84 cells)[3]
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Dosage:10 mg/kg intravenous (i.v.) or a 30 mg/kg intraperitoneal (i.p.) injection
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Administration:IV or IP; after 24 h, PDT was performed
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Result:Pa-PDT, especially i.v. Pa-PDT, significantly inhibited tumor growth up to 70%, while the i.p. Pa-PDT-induced inhibition was up to 43.4% relative to the control group at the end of period.
化学情報
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CAS 番号 15664-29-6
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性状 Solid
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分子量 592.68
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分子式 C35H36N4O5
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Color Blue to dark blue
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SMILES
O=C([C@@H]1/C(C(NC(/C=C2C(CC)=C3C)=C4C)=C4C1=O)=C(N=C(/C=C(C(C)=C/5C=C)\NC5=C/C3=N/2)[C@H]6C)\[C@H]6CCC(O)=O)OC
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別名
フェオフォルバイドA
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Structure Classification
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Initial Source
Botrytis cinerea
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
溶剤 & 溶解度
DMSO : 2 mg/mL (3.37 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Methanol : < 1 mg/mL (insoluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (281 KB)
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SDS (394 KB)
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- Deutsch - DE (394 KB)
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- Portuguese - PT (394 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Jihye Kim, et al. Pheophorbide a identified in an Eupatorium perfoliatum extract is a novel lymphatic vascular activator. Biomed Pharmacother. 2022 Mar;147:112664. [Content Brief]
[2]. Tang PM, et al. Pheophorbide a, an active compound isolated from Scutellaria barbata, possesses photodynamic activities by inducing apoptosis in human hepatocellular carcinoma. Cancer Biol Ther. 2006 Sep;5(9):1111-6. [Content Brief]
[3]. Ahn MY, et al. Pheophorbide a-mediated photodynamic therapy induces apoptotic cell death in murine oral squamous cell carcinoma in vitro and in vivo. Oncol Rep. 2012 Jun;27(6):1772-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6873 mL | 8.4363 mL | 16.8725 mL | 42.1813 mL |
Pheophorbide A 関連分類
HY-125665 関連分類
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