Phthalocyanine
Based on 1 Customer Validation
Phthalocyanine is a type of pigment and Photosensitizer. Upon irradiation, Phthalocyanine generates ROS or converts light energy into heat, inducing oxidative damage, cytotoxicity, and photodynamic killing of bacterial biofilms. Phthalocyanine produces chemiluminescence when oxidized. It can be used in studies related to cancer, bacterial infections, and photodynamic approaches.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.0%
- CAS 番号: 574-93-6
- 分子式: C32H18N8
- 分子量:514.54
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保管条件:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Phthalocyanine exhibits photodynamic cytotoxicity in unspecified cancer cells, with a light IC50 of 0.55 μM, a singlet oxygen quantum yield of 0.57, and extremely low dark cytotoxicity (dark IC50 >100 μM)[1].
Phthalocyanine exerts photodynamic cytotoxicity against HUVEC, breast cancer cell lines MCF-7 and MDA-MB-231, with IC50 values of 45.6 μM, 69.1 μM and 89.3 μM under light exposure[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 574-93-6
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性状 Solid
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分子量 514.54
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分子式 C32H18N8
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Color Dark purple to black
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SMILES
[H]N1C2=C3C=CC=CC3=C1/N=C4C5=C(C(/N=C6C7=C(/C(N/6[H])=N/C8=N/C(C9=C8C=CC=C9)=N\2)C=CC=C7)=N/4)C=CC=C5
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
溶剤 & 溶解度
Acetone : < 1 mg/mL (insoluble)
DMF : < 1 mg/mL (insoluble)
純度とドキュメンテーション
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データシート (280 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Rennie CC, et al. Targeted cancer phototherapy using phthalocyanine-anticancer drug conjugates. Dalton transactions (Cambridge, England : 2003). 2022 Sep 13;51(35):13157-13175. [Content Brief]
[3]. Spesia MB, et al. Evolution of Phthalocyanine Structures as Photodynamic Agents for Bacteria Inactivation. Chem Rec. 2022 Apr;22(4):e202100292. [Content Brief]
[4]. Jiang Z, et al. Pharmaceutical development, composition and quantitative analysis of phthalocyanine as the photosensitizer for cancer photodynamic therapy. J Pharm Biomed Anal. 2014 Jan;87:98-104. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Phthalocyanine 関連分類
HY-121310 関連分類
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- Phthalocyanine
- 574-93-6
- Bacterial
- Photosensitizer
- Reactive Oxygen Species (ROS)
- Biochemical Assay Reagents
- E. coli
- S. aureus
- S. mitis
- MDA-MB-231 human breast adenocarcinoma cells
- P. aeruginosa
- E. seriolicida
- HUVECs
- HepG2 human hepatocellular carcinoma cells
- MCF-7 human breast adenocarcinoma cells
- EMRSA
- Inhibitor
- inhibitor
- inhibit