country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

製品番号: HY-119126

Copy Link Print Information

PK-3

PK-3 is a cancer cell growth inhibitor with microtubule-binding activity. PK-3 binds to tubulin, disrupts the intracellular microtubule network required for mitosis, and induces cell death. PK-3 can be used in research related to chronic myeloid leukemia.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 932331-38-9
分子式: C₂₁H₂₀N₂O₃S
分子量:380.46

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

PK-3 構造式

CAS 番号: 932331-38-9

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	0.049 μM Compound: 1	Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay	[PMID: 27423028]
HepG2	IC₅₀	0.029 μM Compound: 1	Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 27423028]
HT-1080	EC₅₀	<100 nM Compound: 3, CID 20959075	Growth inhibition of human HT1080 cells after 24 hrs by alamar blue assay Growth inhibition of human HT1080 cells after 24 hrs by alamar blue assay	[PMID: 22247791]
MCF-10A	EC₅₀	<100 nM Compound: 3, CID 20959075	Growth inhibition of human MCF10A cells after 24 hrs by alamar blue assay Growth inhibition of human MCF10A cells after 24 hrs by alamar blue assay	[PMID: 22247791]
PC-3	IC₅₀	0.038 μM Compound: 1	Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay	[PMID: 27423028]
SK-OV-3	IC₅₀	0.047 μM Compound: 1	Antiproliferative activity against human SKOV3 cells after 72 hrs by MTT assay Antiproliferative activity against human SKOV3 cells after 72 hrs by MTT assay	[PMID: 27423028]

体外実験

PK-3 (18-55 nM; 10 to 21 days) induces a form of non-apoptotic cell death that is distinct from ferroptosis in KBM7 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

human chronic myeloid leukemia KBM7 cells
Concentration:

55 nM (initial screening for colony outgrowth); 18 nM (final estimated after 3-day initial incubation with growth medium dilution)
Incubation Time:

10 to 21 days
Result:

Induced a non-ferroptotic form of non-apoptotic cell death in KBM7 cells.
Yielded no significantly enriched genes with gene trap insertions in PK-3-resistant KBM7 colonies.

化学情報

CAS 番号 932331-38-9
分子量 380.46
分子式 C₂₁H₂₀N₂O₃S
SMILES

O=S(N1CCCC2=C1C=CC=C2)(C3=CC=C(C=C3)C4=CN=C(O4)C5CC5)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Dixon SJ, et al. Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death. ACS Chem Biol. 2015;10(7):1604-1609. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

お問い合わせ在庫あり

Other size

お問い合わせ