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製品番号: HY-165375

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Plenolin

Plenolin is an anticancer agent. Plenolin exhibits inhibitory activity against human epidermoid carcinoma cells. Plenolin shows in vivo antitumor activity against ascites carcinosarcoma and lymphocytic leukemia in rodent models. Plenolin can be used for research related to ascites tumors and leukemia.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 34257-95-9
分子式: C₁₅H₂₀O₄
分子量:264.32

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Plenolin 構造式

CAS 番号: 34257-95-9

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生物活性
- 製品説明
- Cellular Effect
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
HEp-2	ED₅₀	0.81 μg/mL Compound: 12	Cytotoxicity against human Hep2 cells assessed as growth inhibition by microtiter method Cytotoxicity against human Hep2 cells assessed as growth inhibition by microtiter method	[PMID: 671468]
HEp-2	ED₅₀	0.814 μg/mL Compound: 3	Cytotoxicity against human Hep2 cells Cytotoxicity against human Hep2 cells	[PMID: 845864]
HepG2	ED₅₀	0.8 μg/mL Compound: 6	Cytotoxicity against human HepG2 cells Cytotoxicity against human HepG2 cells	[PMID: 20187635]

体外実験

Plenolin (Compound 3) exhibits a cytotoxic ED₅₀ of 0.814 μg/mL against H.Ep.-2 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Plenolin (33.3 mg/kg; i.p.; once daily for 7 days) exerts 100.0% inhibitory effect on the growth of Ehrlich ascites carcinoma in male CF₁ mice, completely suppresses ascites accumulation, and the survival rate of treated mice reaches 100% on day 7^[1].
For male rats bearing Walker 256 ascitic carcinosarcoma, the T/C value of mean survival days is 207 when treated with Plenolin at 2.5 mg/kg via i.p. administration^[1].
Plenolin (25 mg/kg; i.p.) results in a T/C value of 134 for mean survival days in male DBA/2 mice inoculated with P388 leukemia^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

CF₁ (male, ~30 g, implanted with 10⁶ Ehrlich ascites carcinoma cells)^[1]
Dosage:

33.3 mg/kg/day
Administration:

i.p.; daily
Result:

Achieved 100.0% inhibition of tumor growth.
Reduced ascites-crit to 0.
Reduced total ascites fluid volume to 0.0 mL.
Ensured 100% survival of 5 treated mice to day 7.

化学情報

CAS 番号 34257-95-9
分子量 264.32
分子式 C₁₅H₂₀O₄
SMILES

C[C@@]12[C@]([C@H](C)C[C@@]3([C@]([C@@H]1O)([C@H](C)C(=O)O3)[H])[H])(C=CC2=O)[H]
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Hall IH, et al. Antitumor agents. 21. A proposed mechanism for inhibition of cancer growth by tenulin and helenalin and related cyclopentenones. J Med Chem. 1977;20(3):333-337. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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