Polysuccinimide
Polysuccinimide is a polyimide precursor. Polysuccinimide can hydrolyze to polyaspartic acid (PASP), which has good biocompatibility and low toxicity. PASP can chelate Ca2+ and iron ions, exerting effects of inhibiting vascular calcification and scavenging ROS. Polysuccinimide is commonly used for enzyme immobilization and as a carrier for hydrophobic payloads, and its composites can impart antibacterial or wound-healing-promoting functions. Polysuccinimide can be used in research on cancer and chronic kidney disease-related vascular calcification.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 31586-29-5
- 分子量:60000 (Average)
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
Polysuccinimide (25-200 μg/mL; 24 h) increases the proliferation of HepG2 human hepatocellular carcinoma cells[1].
Polysuccinimide (25-200 μg/mL; 24 h) inhibits the proliferation of 4T1 mouse breast cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:3T3 murine fibroblast cells
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Concentration:25, 50, 100, 200 μg/mL
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Incubation Time:24 h; MTT 4 h
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Result:3T3 cell proliferation was 100.38% at 25 μg/mL, 100.12% at 50 μg/mL, 95.03% at 100 μg/mL, and 89.36% at 200 μg/mL.
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Cell Line:HeLa human cervical adenocarcinoma cells
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Concentration:25, 50, 100, 200 μg/mL
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Incubation Time:24 h; MTT 4 h
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Result:HeLa cell proliferation was 91.45% at 25 μg/mL, 88.98% at 50 μg/mL, 83.95% at 100 μg/mL, and 78.56% at 200 μg/mL.
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Cell Line:HepG2 human hepatocellular carcinoma cells
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Concentration:25, 50, 100, 200 μg/mL
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Incubation Time:24 h; MTT 4 h
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Result:HepG2 cell proliferation was 132.79% at 25 μg/mL, 128.13% at 50 μg/mL, 120% at 100 μg/mL, and 91.16% at 200 μg/mL.
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Cell Line:4T1 murine breast cancer cells
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Concentration:25, 50, 100, 200 μg/mL
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Incubation Time:24 h; MTT 4 h
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Result:4T1 cell proliferation was 107% at 25 μg/mL, 105.18% at 50 μg/mL, 95.22% at 100 μg/mL, and 79.32% at 200 μg/mL.
化学情報
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CAS 番号 31586-29-5
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分子量 60000 (Average)
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SMILES
CC1CC(N(C)C1=O)=O.[n]
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Polysuccinimide 関連分類
HY-172383 関連分類
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Keywords
- Polysuccinimide
- 31586-29-5
- Biochemical Assay Reagents
- 4T1
- Escherichia coli
- HeLa
- HepG2
- MOVAS
- PDLSCs
- RAW264.7
- SH-SY5Y
- antiproliferative
- apoptosis
- breast cancer
- calcium chelation
- cervical cancer
- enzyme immobilization
- fibroblast
- hydrophobic cargo carriers
- iron chelation
- proliferation
- reactive oxygen species
- tumor cell survival
- vascular calcification
- Inhibitor
- inhibitor
- inhibit