PRO-905
Pro-905 is a phosphite peptide with antitumor activity. Pro-905 delivers the active nucleotide antimetabolite thioguanosine monophosphate (TGMP) to the tumor. Pro-905 effectively prevents incorporation of purine salvage substrates into nucleic acids and inhibits colony formation in human malignant peripheral nerve sheath tumors (MPNST) cells. Pro-905 inhibits purine salvage incorporation to nucleic acids and prevents cell growth. Pro-905 inhibits the growth of MPNST and enhances the anti-tumor efficacy of JHU395 (HY-124778) .
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- CAS 番号: 2762209-68-5
- 分子式: C22H29N6O8PS
- 分子量:568.54
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Pro-905 (10 µM, 120 h) inhibits cell proliferation and guanine incorporation to newly synthesized DNA and RNA using JH-2-002 cells with JHU395 (HY-124778) 1 µM, 120 h[1].
Pro-905 (10 µM, 120 h) inhibits colony formation in sNF96.2 and JH-2-002 human MPNST cell with JHU395 (1 µM, 120 h)[1].
Pro-905 (10 µM, 6 h) inhibits purine salvage-dependent 3H-hypoxanthine incorporation to DNA and RNA in sNF96.2 cells[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:sNF96.2 and JH-2-002 human MPNST cells
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Concentration:10 µM (in combination with JHU395 (HY-124778)(1µM))
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Incubation Time:120 h
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Result:Inhibited cell proliferation with effects on nucleic acid and induced DNA damage (γH2AX).
Pro-905 (10 mg/kg, i.p, 5 d/week) in B6 mice with flank MPNST inhibits tumor nucleotide metabolism and abrogates MPNST proliferation with JHU395 (1.2 mg/kg, p.o.) [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:B6 mice with flank MPNST[1]
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Dosage:10 mg/kg (in combination with JHU3955 (1.2 mg/kg, p.o.))
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Administration:Intraperitoneal injection
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Result:Prevented growth of established tumors to a greater extent.
Induced tumors significantly decrease, mean percent proliferation, JHU395 0.82%, Pro-905 1.25%, combination 0.18%.
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Animal Model:Nod scid gamma (NSG) mice with JH-2-031 MPNST [1]
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Dosage:20 mg/kg
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Administration:Intraperitoneal injection
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Result:Caused animal body weights remained within 10% of starting weights over two weeks of dosing.
化学情報
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CAS 番号 2762209-68-5
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分子量 568.54
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分子式 C22H29N6O8PS
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SMILES
O[C@H]1[C@@H](O)[C@H](N2C(N=C(N)NC3=S)=C3N=C2)O[C@@H]1COP(N[C@H](C(OC(C)C)=O)C)(OC4=CC=CC=C4)=O
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別名
MK-905
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
PRO-905 関連分類
HY-155995 関連分類
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