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製品番号: HY-179330

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PSMA-1092

PSMA-1092 is a fluorescent probe targeting prostate-specific membrane antigen (PSMA). PSMA-1092 binds to PSMA through two Glu-urea-Lys motifs and inhibits its glutamate carboxypeptidase activity, with a human K_i of 80 pM. PSMA-1092 accumulates in PSMA-positive tumors, and co-injection of a PSMA inhibitor reduces tumor signal. PSMA-1092 can be used for research on prostate cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2481214-35-9
分子式: C₅₀H₆₂N₁₂O₁₆S₂
分子量:1151.23

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (279 KB)

PSMA-1092 構造式

CAS 番号: 2481214-35-9

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

^[1]

glutamate carboxypeptidase

PSMA

80 pM (Ki)

体外実験

PSMA-1092 (0.01 nM-1 μM; 120 min) inhibits PSMA in LNCaP cell lysates with a K_i of 80 pM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Anti-cancer

PSMA-1092 (2.5 mg/kg; tail vein injection; single administration) exhibits excellent imaging performance, high contrast, and good resolution in LNCaP tumor-bearing mice, making it suitable for NIR-II imaging^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

LNCaP tumor-bearing mice^[1]
Dosage:

2.5 mg/kg
Administration:

tail vein injection; single administration
Result:

Two hours after injection, probe enrichment was visible in the tumor; by 4 hours, the tumor could be clearly distinguished from the surrounding normal tissue.

Related Protocols :

How to Select the Route of Administration for Mammals

化学情報

CAS 番号 2481214-35-9
分子量 1151.23
分子式 C₅₀H₆₂N₁₂O₁₆S₂
SMILES

OC(CC[C@@H](C(O)=O)NC(N[C@H](C(O)=O)CCCCNC(CCN(C1=CC=C(C=C1)C2=C(N=S=N3)C3=C(C4=CC=C(C=C4)N(C)CCC(NCCCC[C@@H](C(O)=O)NC(N[C@H](C(O)=O)CCC(O)=O)=O)=O)C5=NSN=C25)C)=O)=O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (279 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Zhang L, et al. Visualizing Tumors in Real Time: A Highly Sensitive PSMA Probe for NIR-II Imaging and Intraoperative Tumor Resection. Journal of medicinal chemistry. 2021 Jun 10;64(11):7735-7745. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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