Pyridaben
Based on 2 publication(s) in Google Scholar
Pyridaben is a mitochondrial electron transport inhibitor (METI) acaricide that promotes the formation of damaging oxygen and nitrogen radicals. Pyridaben selectively inhibits complex I (NADH dehydrogenase) with an IC50 value of 2.4 nM (assay sites: rat liver and bovine heart mitochondria). Pyridaben also significantly inhibits rat mitochondrial mtNOS function.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.18%
- CAS 番号: 96489-71-3
- 分子式: C19H25ClN2OS
- 分子量:364.93
-
保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
-
Anti-Infection Compound Library
HY-L002
-
Antiparasitic Compound library
HY-L082
-
Human Metabolite Library
HY-L123
-
Mitochondrial Toxicity Compound Library
HY-L155
-
Highly Selective Inhibitors Library
HY-L158
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Bioactive Compound Library
HY-L001
-
Pesticide Compound Library
HY-L183
-
High-Throughput Bioactive Compound Library
HY-L205
-
Mass Spectrometry Human Metabolite Library
HY-L215
-
Environmental Pollutant Compound Library
HY-L247
MedChemExpress（MCE）の使用を引用している文献 Pyridaben
MoreParasite アイソフォーム固有の製品をすべて表示
More
生物活性
|
Mite |
Pyridaben (0-10 µM; 3 min) selectively inhibits complex I-III in rat brain submitochondrial particles[1].
Pyridaben (0-10 µM; 3 min) leads to marked decrease in respiratory control (IC50 = 1.7 µM) in a dose-dependent manner, in rat brain mitochondria (malate-glutamate as substrate)[1].
Pyridaben (0-10 µM; 3 min) produces a marked decrease in mtNOS functional activity, when malate-glutamate is used as substrate, but not when the substrate is succinate.[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Rat brain submitochondrial particles
-
Concentration:0-10 µM
-
Incubation Time:3 min
-
Result:Led to a decrease of NADH-cytochrome reductase activity (complex I-III) and without modification of succinate-cytochrome c reductase activity (complex II-III) and of cytochrome oxidase activity (complex IV)
-
Cell Line:Rat brain mitochondria
-
Concentration:0-10 µM
-
Incubation Time:3 min
-
Result:Showed a marked and dose-dependent decrease in respiratory control in the presence of malate-glutamate as substrate (IC50=1.7 µM)
化学情報
-
CAS 番号 96489-71-3
-
性状 Solid
-
分子量 364.93
-
分子式 C19H25ClN2OS
-
Color Off-white to light yellow
-
SMILES
O=C1C(Cl)=C(SCC2=CC=C(C(C)(C)C)C=C2)C=NN1C(C)(C)C
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (2)
-
Journal Impact Factor
-
Most Recent
-
ACS Environ Au
Machine Learning-Assisted Recognition of Environmental Sulfur-Containing Chemicals in Nontargeted Mass Spectrometry Analysis of Inadequate Mass Resolution. [Abstract]2025 Aug 5;5(6):573-582. PMID: 41277996 -
Fish Shellfish Immunol
α7-nAChR activation mitigates pyridaben-induced hepatotoxicity in grass carp (Ctenopharyngodon idella) via SIRT3 restoration and NF-κB/NLRP3 pathway inhibition. [Abstract]2026 Jul:174:111339. PMID: 41966317
溶剤 & 溶解度
DMSO : 50 mg/mL (137.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (6.85 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
-
データシート (274 KB)
-
SDS (624 KB)
- English - EN (624 KB)
- Français - FR (624 KB)
- Deutsch - DE (624 KB)
- Norwegian - NO (624 KB)
- Español - ES (624 KB)
- Swedish - SV (624 KB)
- Italian - IT (624 KB)
- Korean - KR (624 KB)
- Portuguese - PT (624 KB)
-
取扱説明書 (2659 KB)
参考文献
[1]. Gomez C,et al. Pesticides and impairment of mitochondrial function in relation with the parkinsonian syndrome. Front Biosci. 2007 Jan 1;12:1079-93. [Content Brief]
[2]. Namin HH, et al. Resistance to pyridaben in Canadian greenhouse populations of two-spotted spider mites, Tetranychus urticae (Koch). Pestic Biochem Physiol. 2020 Nov;170:104677. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7403 mL | 13.7013 mL | 27.4025 mL | 68.5063 mL |
| 5 mM | 0.5481 mL | 2.7403 mL | 5.4805 mL | 13.7013 mL | |
| 10 mM | 0.2740 mL | 1.3701 mL | 2.7403 mL | 6.8506 mL | |
| 15 mM | 0.1827 mL | 0.9134 mL | 1.8268 mL | 4.5671 mL | |
| 20 mM | 0.1370 mL | 0.6851 mL | 1.3701 mL | 3.4253 mL | |
| 25 mM | 0.1096 mL | 0.5481 mL | 1.0961 mL | 2.7403 mL | |
| 30 mM | 0.0913 mL | 0.4567 mL | 0.9134 mL | 2.2835 mL | |
| 40 mM | 0.0685 mL | 0.3425 mL | 0.6851 mL | 1.7127 mL | |
| 50 mM | 0.0548 mL | 0.2740 mL | 0.5481 mL | 1.3701 mL | |
| 60 mM | 0.0457 mL | 0.2284 mL | 0.4567 mL | 1.1418 mL | |
| 80 mM | 0.0343 mL | 0.1713 mL | 0.3425 mL | 0.8563 mL | |
| 100 mM | 0.0274 mL | 0.1370 mL | 0.2740 mL | 0.6851 mL |
Pyridaben 関連分類
HY-B0817 関連分類
Powered by Bioz