RA375
Based on 1 Customer Validation
RA375 is a RPN13 (26S proteasome regulatory subunit) inhibitor. RA375 activates UPR signaling, ROS production and apoptosis. RA375 exhibits ten-fold greater activity against cancer lines than RA190, reflecting its nitro ring substituents and the addition of a chloroacetamide warhead.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.87%
- CAS 番号: 2649154-57-2
- 分子式: C30H25ClN4O7
- 分子量:589.00
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Apoptosis Compound Library
HY-L003
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Immunology/Inflammation Compound Library
HY-L007
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Metabolism/Protease Compound Library
HY-L012
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NF-κB Signaling Compound Library
HY-L014
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Anti-Cancer Compound Library
HY-L025
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Anti-Aging Compound Library
HY-L034
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Ubiquitination Compound Library
HY-L050
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Anti-Blood Cancer Compound Library
HY-L079
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Heterocyclic Compound Library
HY-L138
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Protease Inhibitor Library
HY-L147
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Cell Death Library
HY-L162
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Anti-Hematopathy Compound Library
HY-L171
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
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High-Throughput Bioactive Compound Library
HY-L205
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Posttranslational Modification Library
HY-L226
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Lactylation Compound Library
HY-L249
生物活性
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:RA375 (10 mg/kg, ip) inhibits proteasome function and reduces ovarian tumor burden in mice[1].
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Dosage:10 mg/kg.
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Administration:IP for a 5 days on, 2 days off cycle for two weeks.
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Result:Reduced ovarian tumor burden in mice.
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Animal Model:Female Balb/c mice[1].
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Dosage:5, 10, 20, 40, 60, 100 mg/kg (Pharmacological Analysis).
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Administration:IP single dose.
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Result:The dose of 40 mg/kg on alternate days for two weeks produced no observable toxicities or weight loss.
化学情報
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CAS 番号 2649154-57-2
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性状 Solid
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分子量 589.00
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分子式 C30H25ClN4O7
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Color Light yellow to yellow
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SMILES
O=C([C@@H](NC(CCl)=O)CC1=CC=CC=C1)N(C/C(C/2=O)=C\C3=CC=C([N+]([O-])=O)C=C3)CC2=C/C4=CC=C([N+]([O-])=O)C=C4
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 100 mg/mL (169.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6978 mL | 8.4890 mL | 16.9779 mL | 42.4448 mL |
| 5 mM | 0.3396 mL | 1.6978 mL | 3.3956 mL | 8.4890 mL | |
| 10 mM | 0.1698 mL | 0.8489 mL | 1.6978 mL | 4.2445 mL | |
| 15 mM | 0.1132 mL | 0.5659 mL | 1.1319 mL | 2.8297 mL | |
| 20 mM | 0.0849 mL | 0.4244 mL | 0.8489 mL | 2.1222 mL | |
| 25 mM | 0.0679 mL | 0.3396 mL | 0.6791 mL | 1.6978 mL | |
| 30 mM | 0.0566 mL | 0.2830 mL | 0.5659 mL | 1.4148 mL | |
| 40 mM | 0.0424 mL | 0.2122 mL | 0.4244 mL | 1.0611 mL | |
| 50 mM | 0.0340 mL | 0.1698 mL | 0.3396 mL | 0.8489 mL | |
| 60 mM | 0.0283 mL | 0.1415 mL | 0.2830 mL | 0.7074 mL | |
| 80 mM | 0.0212 mL | 0.1061 mL | 0.2122 mL | 0.5306 mL | |
| 100 mM | 0.0170 mL | 0.0849 mL | 0.1698 mL | 0.4244 mL |
RA375 関連分類
HY-136563 関連分類
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