Ravidasvir
Ravidasvir (PPI-668) is an orally active pan-genotypic NS5A inhibitor and antiviral agent. Ravidasvir exhibits antiviral activity against HCV genotypes 1 to 6, with EC50 values ranging from 0.04 to 1.14 nM. Ravidasvir shows no or extremely low activity against feline infectious peritonitis virus type II. Ravidasvir can be used in research related to hepatitis C virus infection.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1242087-93-9
- 分子式: C42H50N8O6
- 分子量:762.91
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Huh-7 | EC50 |
0.007 nM
Compound: 25
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Antiviral activity against HCV genotype 1b Con1 infected in human HuH7 cells assessed as inhibition of viral RNA replication after 3 days by renilla luciferase reporter gene assay
Antiviral activity against HCV genotype 1b Con1 infected in human HuH7 cells assessed as inhibition of viral RNA replication after 3 days by renilla luciferase reporter gene assay
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[PMID: 24320933] |
| Huh-7 | EC50 |
0.071 nM
Compound: 25
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Antiviral activity against HCV genotype 1a H77 infected in human HuH7 cells assessed as inhibition of viral RNA replication after 3 days by renilla luciferase reporter gene assay
Antiviral activity against HCV genotype 1a H77 infected in human HuH7 cells assessed as inhibition of viral RNA replication after 3 days by renilla luciferase reporter gene assay
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[PMID: 24320933] |
体外実験
Ravidasvir potently inhibits HCV genotypes 1 to 6 with EC50 values of 0.04 to 1.14 nM[2].
Ravidasvir (10 μM; 72 h) exhibits absent-to-minimal anti-FIPV serotype II activity and causes cytotoxicity at 10 μM in CRFK cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Parmacokinetics
| Species | Dose | Route | AUC0-24 | AUC0-∞ | Cmax | Tmax | T1/2 | MRT0-∞ | CL/F |
|---|---|---|---|---|---|---|---|---|---|
| Rat[1] | 35 mg/kg | p.o. | 811.25 ng·h/mL | 893.09 ng·h/mL | 132.35 ng/mL | 4.00 h | 3.24 h | 5.56 h | 0.0419 |
化学情報
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CAS 番号 1242087-93-9
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分子量 762.91
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分子式 C42H50N8O6
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SMILES
C([C@@H](NC(OC)=O)C(C)C)(=O)N1[C@H](C=2NC=3C(N2)=CC=C(C3)C4=CC5=C(C=C4)C=C(C=C5)C=6NC(=NC6)[C@H]7N(C([C@@H](NC(OC)=O)C(C)C)=O)CCC7)CCC1
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別名
PPI-668
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Hefnawy M, et al. Validated Microwell-Based Spectrofluorimetric Method for Quantification of Ravidasvir (New Anti-Chronic Hepatitis C Virus-GT4) in Rat Plasma and Its Application to Pharmacokinetic Study. Drug Des Devel Ther. 2020;14:4377-4385. Published 2020 Oct 20. [Content Brief]
[2]. Wu G, et al. Pharmacokinetics, Safety, and Tolerability of Ravidasvir, with and without Danoprevir/Ritonavir, in Healthy Subjects. Antimicrob Agents Chemother. 2021;65(10):e0060021. [Content Brief]
[3]. Cook SE, et al. Investigation of monotherapy and combined anticoronaviral therapies against feline coronavirus serotype II in vitro. J Feline Med Surg. 2022;24(10):943-953. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Ravidasvir 関連分類
HY-17619 関連分類
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