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製品番号: HY-109072

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Riamilovir

1 Cited Publications

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

Riamilovir is an oral, broad-spectrum antiviral agent. Riamilovir can directly act on the virus's RNA-dependent RNA polymerase, thereby inhibiting viral replication, reducing viral load, and helping to alleviate the severity of the disease. Riamilovir can be used in research on acute respiratory viral infections caused by novel variants of SARS-CoV-2.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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CAS 番号: 123606-06-4
分子式: C₅H₄N₆O₃S
分子量:228.19

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Riamilovir 構造式

CAS 番号: 123606-06-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体内実験
- 臨床実験
化学情報
Publications (1)
純度とドキュメンテーション
参考文献
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関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

RNA Polymerase

DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK-293T	CC₅₀	1513 μM Compound: Triazavirin	Cytotoxicity against human HEK293T cells measured after 72 hrs by MTT assay Cytotoxicity against human HEK293T cells measured after 72 hrs by MTT assay	[PMID: 33705902]
MDCK	CC₅₀	368 μM Compound: Triazavirin	Cytotoxicity against MDCK cells by MTT assay Cytotoxicity against MDCK cells by MTT assay	[PMID: 33705902]

体内実験

Riamilovir (250 mg capsules, once daily; orally for 10 consecutive days) demonstrated broad-spectrum antiviral activity against influenza, tick-borne encephalitis, and SARS-CoV-2 in a randomized, double-blind, multicenter trial. It was able to reduce the viral load of SARS-CoV-2 in vivo without severe adverse reactions^[1].
Riamilovir (0.85 mg/kg; orally once daily for 7 consecutive days) produced a significant endothelial protective effect in male C57BL/6 mice with endothelial dysfunction induced by L-NAME. This substance reduced the levels of MMP-2 and MMP-9 in the aortic supernatant of mice by 20.4% and 19.5%, respectively, and downregulated the level of iNOS in the aorta by 57.2% and upregulated the level of eNOS by 40.0%^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

臨床実験

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

化学情報

CAS 番号 123606-06-4
分子量 228.19
分子式 C₅H₄N₆O₃S
SMILES

O=C1N(N=C(SC)N2)C2=NN=C1[N+]([O-])=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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J Med Virol

Drug Repurposing: In Vitro Evaluation of Simeprevir as a Novel Antiviral Drug Against Severe Fever With Thrombocytopenia Syndrome Virus. [Abstract]

2025 Oct;97(10):e70655. PMID: 41117261

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (272 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Sabitov AU, et al. Results of a randomized double-blind multicenter clinical trial of the efficacy and safety of the drug riamilovir for the prevention of COVID-19. Terapevticheskii Arkhiv, 2024, 96(3):280-285.

[2]. Haritonova O, et al. Evaluation of the Endothelioprotective Effect of Certain Antiviral Agents in Conditions of Experimental Endothelial Dysfunction. Crimea Journal of Experimental and Clinical Medicine, 2025.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Riamilovir

1 Cited Publications

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生物活性
- 製品説明
- IC₅₀ & Target
- 体内実験
- 臨床実験
化学情報
Publications (1)
純度とドキュメンテーション
参考文献

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Riamilovir

MedChemExpress（MCE）の使用を引用している文献 Riamilovir

DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (1)

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Riamilovir 関連分類

HY-109072 関連分類