RIP3 activator 1
RIP3 activator 1 (compound C8) is a potent RIP3 activator. RIP3 activator 1 inhibits cell growth. RIP3 activator 1 induces necroptosis through the RIP3/p62/Keap1 signaling pathway. RIP3 activator 1 increases the protein expression of p-MLKL. RIP3 activator 1 induces autophagy. RIP3 activator 1 increases accumulation of LC3-II and p62 protein expression.
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- CAS 番号: 1456899-52-7
- 分子式: C26H50N4O3
- 分子量:466.70
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| EC9706 | IC50 |
2.29 μM
Compound: 14h
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Antiproliferative activity against human EC9706 cells after 48 hrs by MTT assay
Antiproliferative activity against human EC9706 cells after 48 hrs by MTT assay
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[PMID: 24835817] |
| MCF7 | IC50 |
1.93 μM
Compound: 14h
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Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
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[PMID: 24835817] |
| MGC-803 | IC50 |
3.11 μM
Compound: 14h
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Antiproliferative activity against human MGC803 cells after 48 hrs by MTT assay
Antiproliferative activity against human MGC803 cells after 48 hrs by MTT assay
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[PMID: 24835817] |
化学情報
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CAS 番号 1456899-52-7
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分子量 466.70
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分子式 C26H50N4O3
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SMILES
O[C@@H]1[C@@H](N)CO[C@H]1COCC(N=N2)=CN2CCCCCCCCCCCCCCCCCC
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
RIP3 activator 1 関連分類
HY-168640 関連分類
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