RJ-34
RJ-34, an aristolactam analogue, exhibits potent antitumor activities against a broad array of cancer cell lines with GI50 values in the subnanomolar range (GI50 <0.1 nM for A431, MES-SA, MES-SA/DX5, HCT-15, and HCT-15/CLO2 cells).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1170694-29-7
- 分子式: C22H22N2O5
- 分子量:394.42
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性
製品説明
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A-431 | GI50 |
<0.0001 μM
Compound: 34
|
Antiproliferative activity against human A431 cells by SRB assay
Antiproliferative activity against human A431 cells by SRB assay
|
[PMID: 19394218] |
| A-431 | GI50 |
<0.1 nM
Compound: 34
|
Antiproliferative activity against human A431 cells by SRB assay
Antiproliferative activity against human A431 cells by SRB assay
|
[PMID: 19394218] |
| A549 | GI50 |
<0.1 μM
Compound: 34
|
Antiproliferative activity against human A549 cells by SRB assay
Antiproliferative activity against human A549 cells by SRB assay
|
[PMID: 19394218] |
| HCT-15 | GI50 |
0.0095 μM
Compound: 34
|
Antiproliferative activity against multidrug resistant human HCT15/CLO2 cells by SRB assay
Antiproliferative activity against multidrug resistant human HCT15/CLO2 cells by SRB assay
|
[PMID: 19394218] |
| HCT-15 | GI50 |
<0.0001 μM
Compound: 34
|
Antiproliferative activity against human HCT15 cells by SRB assay
Antiproliferative activity against human HCT15 cells by SRB assay
|
[PMID: 19394218] |
| HCT-15 | GI50 |
<0.1 nM
Compound: 34
|
Antiproliferative activity against human HCT15 cells by SRB assay
Antiproliferative activity against human HCT15 cells by SRB assay
|
[PMID: 19394218] |
| MES-SA | GI50 |
<0.0001 μM
Compound: 34
|
Antiproliferative activity against human MESSA cells by SRB assay
Antiproliferative activity against human MESSA cells by SRB assay
|
[PMID: 19394218] |
| MES-SA | GI50 |
<0.1 nM
Compound: 34
|
Antiproliferative activity against human MESSA cells by SRB assay
Antiproliferative activity against human MESSA cells by SRB assay
|
[PMID: 19394218] |
| MES-SA/Dx5 | GI50 |
<0.0001 μM
Compound: 34
|
Antiproliferative activity against multidrug resistant human MES-SA/Dx5 cells by SRB assay
Antiproliferative activity against multidrug resistant human MES-SA/Dx5 cells by SRB assay
|
[PMID: 19394218] |
| MES-SA/Dx5 | GI50 |
<0.1 nM
Compound: 34
|
Antiproliferative activity against multidrug resistant human MES-SA/Dx5 cells by SRB assay
Antiproliferative activity against multidrug resistant human MES-SA/Dx5 cells by SRB assay
|
[PMID: 19394218] |
| SK-OV-3 | GI50 |
<0.1 μM
Compound: 34
|
Antiproliferative activity against human SKOV3 cells by SRB assay
Antiproliferative activity against human SKOV3 cells by SRB assay
|
[PMID: 19394218] |
化学情報
-
CAS 番号 1170694-29-7
-
分子量 394.42
-
分子式 C22H22N2O5
-
SMILES
O=C1N(CCN(C)C)C2=C3C1=CC(OC)=C(OC)C3=C(C=C4)C(C5=C4OCO5)=C2
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)