RO5487624
RO5487624, an analogue of RO5464466 (HY-120690), is an orally active hemagglutinin (HA) inhibitor of influenza H1N1 viruses that abolishes influenza virus fusion by blocking HA conformational changes in low pH environments. RO5487624 displays a protective effect on mice that are lethally challenged with influenza H1N1 virus.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1399103-28-6
- 分子式: C16H25ClN2O3S
- 分子量:360.90
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MDCK | CC50 |
71.2 μM
Compound: 40
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Cytotoxicity against MDCK cells after 3 days by MTT assay
Cytotoxicity against MDCK cells after 3 days by MTT assay
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[PMID: 24900355] |
| MDCK | EC50 |
0.086 μM
Compound: 40
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Antiviral activity against Influenza A virus (A/Weiss/1943(H1N1)) infected in MDCK cells assessed as inhibition of virus-induced cytopathic effects after 3 days by MTT assay
Antiviral activity against Influenza A virus (A/Weiss/1943(H1N1)) infected in MDCK cells assessed as inhibition of virus-induced cytopathic effects after 3 days by MTT assay
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[PMID: 24900355] |
化学情報
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CAS 番号 1399103-28-6
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分子量 360.90
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分子式 C16H25ClN2O3S
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SMILES
O=S(C1=CC(NC[C@]2(C)CC(C)(C)C[C@H](O)C2)=CC=C1Cl)(N)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
RO5487624 関連分類
HY-116182 関連分類
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