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製品番号: HY-N2037B

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(S)-Higenamine

(別名: (S)-Norcoclaurine)

1 Cited Publications

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

(S)-Higenamine ((S)-Norcoclaurine), a S-enantiomer of Higenamine, is the entry compound in benzylisoquinoline alkaloid biosynthesis. (S)-Higenamine is produced by the condensation of dopamine and 4-hydroxyphenylacetaldehyde (4-HPAA) by norcoclaurine synthase (NCS).

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CAS 番号: 22672-77-1
分子式: C₁₆H₁₇NO₃
分子量:271.31

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

(S)-Higenamine 構造式

CAS 番号: 22672-77-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Endogenous Metabolite アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
Platelet	IC₅₀	1.6 μM Compound: 1S, (S)-(-)-higenamine	Inhibition of epinephrine-induced platelet aggregation in rat blood Inhibition of epinephrine-induced platelet aggregation in rat blood	[PMID: 18556200]
Platelet	IC₅₀	25 μM Compound: 1S, (S)-(-)-higenamine	Inhibition of U46619-induced platelet aggregation in rat blood Inhibition of U46619-induced platelet aggregation in rat blood	[PMID: 18556200]
Platelet	IC₅₀	450 μM Compound: 1S, (S)-(-)-higenamine	Inhibition of collagen-induced platelet aggregation in rat blood Inhibition of collagen-induced platelet aggregation in rat blood	[PMID: 18556200]
Platelet	IC₅₀	9.1 μM Compound: 1S, (S)-(-)-higenamine	Inhibition of NaAA-induced platelet aggregation in rat blood Inhibition of NaAA-induced platelet aggregation in rat blood	[PMID: 18556200]
Platelet	IC₅₀	>1000 μM Compound: 1S, (S)-(-)-higenamine	Inhibition of ADP-induced platelet aggregation in rat blood Inhibition of ADP-induced platelet aggregation in rat blood	[PMID: 18556200]

体外実験

The biosynthetic pathway leading to benzylisoquinoline alkaloids originates from the enzyme-catalyzed condensation of dopamine and 4-hydrophenylacetaldehyde to yield (S)-norcoclaurine. Both substrates are secondary metabolites derived from the decarboxylation/hydroxylation/deamination of tyrosine^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 22672-77-1
分子量 271.31
分子式 C₁₆H₁₇NO₃
SMILES

OC1=CC2=C([C@H](CC3=CC=C(O)C=C3)NCC2)C=C1O
別名

(S)-Norcoclaurine
Structure Classification
- Alkaloids
- Isoquinoline Alkaloids
- Phenols
- Polyphenols
Initial Source
- Endogenous metabolite
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Int J Biol Macromol

Genome-wide identification of O-methyltransferase genes in Stephania yunnanensis and their roles in benzylisoquinoline alkaloid biosynthesis. [Abstract]

2026 Apr:356:151603. PMID: 41876022

純度とドキュメンテーション

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純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (267 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Minami H, et al. Functional analysis of norcoclaurine synthase in Coptis japonica. J Biol Chem. 2007;282(9):6274‐6282. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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濃度 _(終了) 濃度 _(終了)

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

(S)-Higenamine

1 Cited Publications

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Publications (1)
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(S)-Higenamine

MedChemExpress（MCE）の使用を引用している文献 (S)-Higenamine

Endogenous Metabolite アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (1)

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

(S)-Higenamine 関連分類

HY-N2037B 関連分類