(S)-MCOPPB
Based on 1 Customer Validation
(S)-MCOPPB is the S-form of MCOPPB (HY-13101). MCOPPB is an orally active and selective agonist of Nociceptin/Orphanin FQ-Receptor. MCOPPB inhibits signaling through the NOP receptor in the mouse brain. MCOPPB can be used for anxiety disorders study.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.97%
- CAS 番号: 1108147-70-1
- 分子式: C26H40N4
- 分子量:408.62
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Opioid Receptor アイソフォーム固有の製品をすべて表示
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO-K1 | EC50 |
23 nM
Compound: 21
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Agonist activity at human mu opioid receptor expressed in CHOK1 cells by [35S]GTPgammaS binding
Agonist activity at human mu opioid receptor expressed in CHOK1 cells by [35S]GTPgammaS binding
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[PMID: 19125610] |
| CHO-K1 | EC50 |
514 nM
Compound: 21
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Agonist activity at human delta opioid receptor expressed in CHOK1 cells by [35S]GTPgammaS binding
Agonist activity at human delta opioid receptor expressed in CHOK1 cells by [35S]GTPgammaS binding
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[PMID: 19125610] |
| HEK293 | EC50 |
0.5 nM
Compound: 21
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Agonist activity at human NOP receptor expressed in HEK293 cells by [35S]GTPgammaS binding
Agonist activity at human NOP receptor expressed in HEK293 cells by [35S]GTPgammaS binding
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[PMID: 19125610] |
| HEK293 | EC50 |
8.4 nM
Compound: 21
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Agonist activity at human kappa opioid receptor expressed in HEK293 cells by [35S]GTPgammaS binding
Agonist activity at human kappa opioid receptor expressed in HEK293 cells by [35S]GTPgammaS binding
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[PMID: 19125610] |
化学情報
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CAS 番号 1108147-70-1
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性状 Solid
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分子量 408.62
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分子式 C26H40N4
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Color White to off-white
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SMILES
CC1(CCCCCCC1)N2CCC(CC2)N3C([C@H]4CCCNC4)=NC5=CC=CC=C53
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
DMSO : 5 mg/mL (12.24 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Hayashi S, et al. Novel non-peptide nociceptin/orphanin FQ receptor agonist, 1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole: design, synthesis, and structure-activity relationship of oral receptor occupancy in the brain for orally potent antianxiety drug. J Med Chem. 2009 Feb 12;52(3):610-25. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4473 mL | 12.2363 mL | 24.4726 mL | 61.1815 mL |
| 5 mM | 0.4895 mL | 2.4473 mL | 4.8945 mL | 12.2363 mL | |
| 10 mM | 0.2447 mL | 1.2236 mL | 2.4473 mL | 6.1182 mL |
(S)-MCOPPB 関連分類
HY-13101B 関連分類
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