S16–1029
S16–1029 is a selective and orally active butyrylcholinesterase (BChE) inhibitor with IC50s of 11.35 nM and 48.1 nM for eqBChE and hBChE, respectively. S16–1029 could cross the blood-brain barrier (BBB) and reach the central nervous system (CNS). S16–1029 can be used for Alzheimer's disease (AD) research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2653349-51-8
- 分子式: C23H25N7O3
- 分子量:447.49
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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eqBCHE 11.35 nM (IC50) |
hBCHE 48.1 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| SH-SY5Y | IC50 |
89.77 μM
Compound: S16-1029
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Cytotoxicity against human SH-SY5Y cells assessed as survival rate incubated for 24 hrs by MTT assay
Cytotoxicity against human SH-SY5Y cells assessed as survival rate incubated for 24 hrs by MTT assay
|
[PMID: 38452730] |
化学情報
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CAS 番号 2653349-51-8
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分子量 447.49
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分子式 C23H25N7O3
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SMILES
O=C(CN1C(C2=NON=C2N)=NC3=C1C=CC=C3)NC4=CC=C(CCN5CCOCC5)C=C4
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
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