SBP-1750
Based on 1 Customer Validation
SBP-1750 is an orally active ULK inhibitor and an ATG13 degrader. SBP-1750 strongly inhibits ULK1/2 activity, with IC50 values of 8 and 50 nM, respectively. SBP-1750 induces ATG13 degradation, with an EC50 value of 114 nM. SBP-1750 can inhibit autophagy in cancer cells and induce cell death. SBP-1750 can be used in cancer research, such as for pancreatic cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.05%
- CAS 番号: 1884219-70-8
- 分子式: C21H22ClN5O4
- 分子量:443.88
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
ULK1 8 nM (IC50) |
ULK2 50 nM (IC50) |
体外実験
SBP-1750 (5 μM; 18 hours) inhibits autophagy in A549 cells[1].
SBP-1750 (48 h) induces ATG13 degradation in A549 ATG13-HiBiT cells with EC50 of 114 nM[1].
SBP-1750 (48 h) inhibits cell viability in KRAS-mutant cancer cells (A549, MiaPaCa2, NCI-H358, PANC-1) with IC50 <50 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Parmacokinetics
| Species | Dose | Route | T1/2 | Tmax | Cmax | AUC0-t |
|---|---|---|---|---|---|---|
| Mice[1] | 10 mg/kg | p.o. | 2 h | 1 h | 32.9 μM | 135.42 μM/L·h |
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:KPC4662 PDAC mice model[1]
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Dosage:40 mg/kg
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Administration:I.g., daily; from day 10 to 28
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Result:Inhibited tumor growth and metastasis to the liver and intestines.
Increaseed the infiltration of intratumoral CD4+ helper T cells and CD8+ cytotoxic T cells.
化学情報
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CAS 番号 1884219-70-8
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性状 Solid
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分子量 443.88
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分子式 C21H22ClN5O4
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Color White to off-white
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SMILES
O=C(NC)C1=CC=CC=C1NC2=NC(NC3=CC(OC)=C(OC)C(OC)=C3)=NC=C2Cl
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
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データシート (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
SBP-1750 関連分類
HY-179089 関連分類
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