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製品番号: HY-18157

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SCH 900229

SCH 900229 is a potent γ-secretase inhibitor with selective activity against PS1. The Aβ40 IC50 value of SCH 900229 is 1.3 nM, showing its excellent ability in reducing Aβ. SCH 900229 has shown good Aβ-lowering effects after oral administration in preclinical animal models. SCH 900229 has been advanced to human clinical trials for further development of compounds for the inhibition of Alzheimer's disease.

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CAS 番号: 1100361-36-1
分子式: C₂₁H₂₁ClF₂O₆S₂
分子量:506.97

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

SCH 900229 構造式

CAS 番号: 1100361-36-1

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	1 nM Compound: (-)-16, SCH-900229	Inhibition of PS2 gamma-secretase expressed in HEK cells harboring Awe-Lon gene assessed as reduction of amyloid beta-42 production Inhibition of PS2 gamma-secretase expressed in HEK cells harboring Awe-Lon gene assessed as reduction of amyloid beta-42 production	[PMID: 24900404]
HEK293	IC₅₀	1 nM Compound: (-)-1a	Inhibition of gamma secretase-mediated amyloid beta42 production in HEK293 cells transfected with human APPSOW and APPLON after 5 hrs by sandwich immunoassay Inhibition of gamma secretase-mediated amyloid beta42 production in HEK293 cells transfected with human APPSOW and APPLON after 5 hrs by sandwich immunoassay	[PMID: 23265892]
HEK293	IC₅₀	1 nM Compound: 1, SCH 900229	Inhibition of gamma-secretase (unknown origin) expressed in HEK293 cells co-expressing Awe-Lon mutant assessed as reduction of amyloid beta-42 production Inhibition of gamma-secretase (unknown origin) expressed in HEK293 cells co-expressing Awe-Lon mutant assessed as reduction of amyloid beta-42 production	[PMID: 23265902]
HEK293	IC₅₀	1.3 nM Compound: (-)-1a	Inhibition of gamma secretase-mediated amyloid beta40 production in HEK293 cell membranes transfected with human APPSOW and APPLON mutant after 5 hrs by sandwich immunoassay Inhibition of gamma secretase-mediated amyloid beta40 production in HEK293 cell membranes transfected with human APPSOW and APPLON mutant after 5 hrs by sandwich immunoassay	[PMID: 23265892]
HEK293	IC₅₀	1.3 nM Compound: (-)-1a; SCH 900229	Inhibition of gamma-secretase in HEK293 cell membranes expressing human APP Swedish/London double mutant assessed as reduction in amyloid beta 40 formation after 1 hr by electrochemiluminescence based immunoassay Inhibition of gamma-secretase in HEK293 cell membranes expressing human APP Swedish/London double mutant assessed as reduction in amyloid beta 40 formation after 1 hr by electrochemiluminescence based immunoassay	[PMID: 27836402]
HEK293	IC₅₀	1.3 nM Compound: 1, SCH 900229	Inhibition of gamma-secretase (unknown origin) expressed in HEK293 cell membrane co-expressing Awe-Lon mutant assessed as reduction of amyloid beta-40 production Inhibition of gamma-secretase (unknown origin) expressed in HEK293 cell membrane co-expressing Awe-Lon mutant assessed as reduction of amyloid beta-40 production	[PMID: 23265902]
HEK293	IC₅₀	4 nM Compound: (-)-16, SCH-900229	Inhibition of PS1 gamma-secretase expressed in HEK cells harboring Awe-Lon gene assessed as reduction of amyloid beta-40 production Inhibition of PS1 gamma-secretase expressed in HEK cells harboring Awe-Lon gene assessed as reduction of amyloid beta-40 production	[PMID: 24900404]
HEK293	IC₅₀	4 nM Compound: (-)-1a	Inhibition of gamma secretase-mediated amyloid beta40 production in HEK293 cells transfected with human APPSOW and APPLON after 5 hrs by sandwich immunoassay Inhibition of gamma secretase-mediated amyloid beta40 production in HEK293 cells transfected with human APPSOW and APPLON after 5 hrs by sandwich immunoassay	[PMID: 23265892]
HEK293	IC₅₀	4 nM Compound: 1, SCH 900229	Inhibition of gamma-secretase (unknown origin) expressed in HEK293 cells co-expressing Awe-Lon mutant assessed as reduction of amyloid beta-40 production Inhibition of gamma-secretase (unknown origin) expressed in HEK293 cells co-expressing Awe-Lon mutant assessed as reduction of amyloid beta-40 production	[PMID: 23265902]
HEK293	IC₅₀	46 nM Compound: (-)-16, SCH-900229	Inhibition of PS1 gamma-secretase expressed in HEK cells harboring Awe-Lon gene assessed as notch cleavage Inhibition of PS1 gamma-secretase expressed in HEK cells harboring Awe-Lon gene assessed as notch cleavage	[PMID: 24900404]

化学情報

CAS 番号 1100361-36-1
分子量 506.97
分子式 C₂₁H₂₁ClF₂O₆S₂
SMILES

O=S([C@]12C3=C(F)C=CC(F)=C3OC[C@@]1([H])[C@@H](OCC2)CCS(C)(=O)=O)(C4=CC=C(C=C4)Cl)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (273 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Discovery of SCH 900229, a Potent Presenilin 1 Selective γ-Secretase Inhibitor for the Treatment of Alzheimer's Disease

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100 mg

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