Shield-2
Shield-2 is an efficient stabilizing ligand binding to the FKBP (F36V) protein with a dissociation constant of 29 nM. Shield-2 binds tightly to the FKBP mutants destabilizing domains and prevents degradation, thus providing small molecule regulation over intracellular protein levels.
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- CAS 番号: 1013621-70-9
- 分子式: C35H51N3O7
- 分子量:625.80
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| NIH3T3 | EC50 |
1.2 μM
Compound: shield-2
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Binding affinity to human FKBP F36V/L106P mutant-YFP fusion protein expressed in NIH3T3 cells after 24 hrs
Binding affinity to human FKBP F36V/L106P mutant-YFP fusion protein expressed in NIH3T3 cells after 24 hrs
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[PMID: 18039574] |
化学情報
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CAS 番号 1013621-70-9
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分子量 625.80
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分子式 C35H51N3O7
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SMILES
COC(C=C1CC[C@H](C2=CC(OCCN3CCOCC3)=CC=C2)OC([C@H]4N(CCCC4)C(NC(CC)CC)=O)=O)=C(C=C1)OC
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Grimley JS, et al. Synthesis and analysis of stabilizing ligands for FKBP-derived destabilizing domains. Bioorg Med Chem Lett. 2008 Jan 15;18(2):759-61. [Content Brief]
[2]. Bonger KM, et al. Small-molecule displacement of a cryptic degron causes conditional protein degradation. Nat Chem Biol. 2011 Jul 3;7(8):531-7. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Shield-2 関連分類
HY-113646 関連分類
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