Simvastatin hydroxy acid sodium
Based on 1 publication(s) in Google Scholar
Simvastatin hydroxy acid (Tenivastatin) sodium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin hydroxy acid sodium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin hydroxy acid sodium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene.
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- 純度: 99.86%
- CAS 番号: 101314-97-0
- 分子式: C25H39NaO6
- 分子量:458.56
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保管条件:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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MedChemExpress（MCE）の使用を引用している文献 Simvastatin hydroxy acid sodium
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
12 nM
Compound: simvastatin (salt)
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Concentration required to inhibit HMG-CoA reductase by 50% was determined in Hep G2 cell line
Concentration required to inhibit HMG-CoA reductase by 50% was determined in Hep G2 cell line
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[PMID: 1527791] |
| HES | IC50 |
6.5 nM
Compound: simvastatin (salt)
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Concentration required to inhibit HMG-CoA reductase by 50% was determined in HES 9 cell line
Concentration required to inhibit HMG-CoA reductase by 50% was determined in HES 9 cell line
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[PMID: 1527791] |
Simvastatin acid (0.1-20 μM; 24 h) significantly decreases ROS production between 8.9% and 43% in Indoxyl sulfate-treated hCM cells[2].
Simvastatin acid (0.1-20 μM; 24 h) alters the protein expression of OATP3A1 in hCMs and OATP3A1-expressing HEK293 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:hCM and HEK293 (transfected with OATP3A1)
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Concentration:0.1, 1, 10 and 20 μM
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Incubation Time:24 h
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Result:Decreased 1.5% to 90% in OATP3A1 expression with a dose-dependent manner in both hCMs and OATP3A1-expressing cells.
化学情報
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CAS 番号 101314-97-0
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性状 Solid
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分子量 458.56
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分子式 C25H39NaO6
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Color White to light brown
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SMILES
CCC(C)(C)C(O[C@@H]1[C@@]2([H])C(C=C[C@H](C)[C@@H]2CC[C@@H](O)C[C@@H](O)CC(O[Na])=O)=C[C@H](C)C1)=O
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別名
Tenivastatin sodium; Simvastatin Impurity A sodium
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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ACS Nano
Intranasal Carrier-Free Nanomodulator Addresses Both Symptomatology and Etiology of Alzheimer's Disease by Restoring Neuron Plasticity and Reprogramming Lesion Microenvironment. [Abstract]2024 Oct 29;18(43):29779-29793. PMID: 39415568
溶剤 & 溶解度
DMSO : 100 mg/mL (218.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (276 KB)
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SDS (557 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Eduardo Filipe Oliveira, et al. HMG-CoA Reductase inhibitors: an updated review of patents of novel compounds and formulations (2011-2015). Expert Opin Ther Pat. 2016 Nov;26(11):1257-1272. [Content Brief]
[2]. Atilano-Roque A, et al. Characterization of simvastatin acid uptake by organic anion transporting polypeptide 3A1 (OATP3A1) and influence of drug-drug interaction. Toxicol In Vitro. 2017 Dec;45(Pt 1):158-165. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1807 mL | 10.9037 mL | 21.8074 mL | 54.5185 mL |
| 5 mM | 0.4361 mL | 2.1807 mL | 4.3615 mL | 10.9037 mL | |
| 10 mM | 0.2181 mL | 1.0904 mL | 2.1807 mL | 5.4518 mL | |
| 15 mM | 0.1454 mL | 0.7269 mL | 1.4538 mL | 3.6346 mL | |
| 20 mM | 0.1090 mL | 0.5452 mL | 1.0904 mL | 2.7259 mL | |
| 25 mM | 0.0872 mL | 0.4361 mL | 0.8723 mL | 2.1807 mL | |
| 30 mM | 0.0727 mL | 0.3635 mL | 0.7269 mL | 1.8173 mL | |
| 40 mM | 0.0545 mL | 0.2726 mL | 0.5452 mL | 1.3630 mL | |
| 50 mM | 0.0436 mL | 0.2181 mL | 0.4361 mL | 1.0904 mL | |
| 60 mM | 0.0363 mL | 0.1817 mL | 0.3635 mL | 0.9086 mL | |
| 80 mM | 0.0273 mL | 0.1363 mL | 0.2726 mL | 0.6815 mL | |
| 100 mM | 0.0218 mL | 0.1090 mL | 0.2181 mL | 0.5452 mL |
Simvastatin hydroxy acid sodium 関連分類
HY-115292 関連分類
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