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United States

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製品番号: HY-130558

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SL-1-73

SL-1-73 is a tubulin ligand. SL-1-73 exhibits antitumor activity against esophageal squamous cell carcinoma (ESCC) both in vitro and in vivo by inhibiting microtubule assembly, inducing G2/M phase cell cycle arrest and apoptosis, and disrupting tumor blood vessels. SL-1-73 can be used for the research of ESCC and other tumors.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2000199-44-8
分子式: C₂₀H₁₉N₃O₅S
分子量:413.45

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

SL-1-73 構造式

CAS 番号: 2000199-44-8

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
Bel-7402	IC₅₀	1.83 μM Compound: 13k	Antiproliferative activity against human Bel7402 assessed as reduction in cell viability measured after 48 hrs by SRB assay Antiproliferative activity against human Bel7402 assessed as reduction in cell viability measured after 48 hrs by SRB assay	[PMID: 27919655]
HepG2	IC₅₀	0.096 μM Compound: 13k	Antiproliferative activity against human HepG2 assessed as reduction in cell viability measured after 48 hrs by SRB assay Antiproliferative activity against human HepG2 assessed as reduction in cell viability measured after 48 hrs by SRB assay	[PMID: 27919655]
KYSE-140	IC₅₀	0.01 μM Compound: 12c	Antiproliferative activity against human KYSE-140 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 assay Antiproliferative activity against human KYSE-140 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 assay	[PMID: 34838335]
KYSE-30	IC₅₀	0.01 μM Compound: 12c	Antiproliferative activity against human KYSE-30 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 assay Antiproliferative activity against human KYSE-30 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 assay	[PMID: 34838335]
KYSE-410	IC₅₀	0.01 μM Compound: 12c	Antiproliferative activity against human KYSE-410 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 assay Antiproliferative activity against human KYSE-410 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 assay	[PMID: 34838335]
KYSE-510	IC₅₀	0.01 μM Compound: 12c	Antiproliferative activity against human KYSE-510 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 assay Antiproliferative activity against human KYSE-510 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 assay	[PMID: 34838335]
MCF7	IC₅₀	0.45 μM Compound: 13k	Antiproliferative activity against human MCF7 assessed as reduction in cell viability measured after 48 hrs by SRB assay Antiproliferative activity against human MCF7 assessed as reduction in cell viability measured after 48 hrs by SRB assay	[PMID: 27919655]
MIA PaCa-2	IC₅₀	0.43 μM Compound: 13k	Antiproliferative activity against human MIAPaCa2 assessed as reduction in cell viability measured after 48 hrs by SRB assay Antiproliferative activity against human MIAPaCa2 assessed as reduction in cell viability measured after 48 hrs by SRB assay	[PMID: 27919655]

化学情報

CAS 番号 2000199-44-8
分子量 413.45
分子式 C₂₀H₁₉N₃O₅S
SMILES

O=S(NC1=CC=C(OC)N=C1OC)(C2=CC(C3=CC(O)=CC=C3N4C)=C4C=C2)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (269 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Niu F, et al. Novel carbazole sulfonamide microtubule-destabilizing agents exert potent antitumor activity against esophageal squamous cell carcinoma. Cancer Lett. 2018 Apr 28;420:60-71. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

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分子量分子量

希釈計算機

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濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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