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Solbinsiran

(別名: LY3561774)

Solbinsiran (LY3561774) is a GalNAc-conjugated siRNA targeting ANGPTL3. Solbinsiran mediates RNA interference against hepatic ANGPTL3 mRNA, reducing ANGPTL3 translation. Solbinsiran lowers hepatocyte ANGPTL3 mRNA and serum ANGPTL3 protein levels. Solbinsiran can be used in research on mixed dyslipidemia.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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  • CAS 番号: 2718150-11-7
  • 分子式: C653H859O412N229F11P57S6
  • 分子量:20674.90
  • 保管条件:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Solbinsiran Chemical Structure
    Solbinsiran 構造式
CAS 番号: 2718150-11-7
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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
最寄りの代理店をお探しください Your local distributor: Hycultec GmbHHycultec
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  • Solbinsiran Chemical Structure
    Solbinsiran Chemical Structure RNA, ([4'-de(hydroxymethyl)-4'-[(hydroxymethoxyphosphinyl)methoxy]]Um-sp-(2'-deoxy-2'-fluoro)G-sp-(2'-deoxy-2'-fluoro)U-sp-(2'-deoxy-2'-fluoro)A-(2'-deoxy-2'-fluoro)U-Am-(2'-deoxy-2'-fluoro)A-Cm-Cm-(2'-deoxy-2'-fluoro)U-Um-Cm-Cm-(2'-deoxy-2'-fluoro)A-Um-Um-Um-Um-Gm-Am-sp-Gm-sp-Gm), complex with RNA (Um-sp-Cm-Am-Am-Am-Am-Um-(2'-deoxy-2'-fluoro)G-(2'-deoxy-2'-fluoro)G-(2'-deoxy-2'-fluoro)A-(2'-deoxy-2'-fluoro)A-Gm-Gm-Um-Um-Am-Um-Am-Cm-Am-Gm-Cm-Am-Gm-Cm-Cm-Gm-[2'-O-[[2-[2-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]ethoxy]ethoxy]methyl]]A-[2'-O-[[2-[2-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]ethoxy]ethoxy]methyl]]A-[2'-O-[[2-[2-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]ethoxy]ethoxy]methyl]]A-Gm-Gm-Cm-Um-Gm-Cm) (1:1)
    1/16
  • RNA, ([4'-de(hydroxymethyl)-4'-[(hydroxymethoxyphosphinyl)methoxy]]Um-sp-(2'-deoxy-2'-fluoro)G-sp-(2'-deoxy-2'-fluoro)U-sp-(2'-deoxy-2'-fluoro)A-(2'-deoxy-2'-fluoro)U-Am-(2'-deoxy-2'-fluoro)A-Cm-Cm-(2'-deoxy-2'-fluoro)U-Um-Cm-Cm-(2'-deoxy-2'-fluoro)A-Um-Um-Um-Um-Gm-Am-sp-Gm-sp-Gm), complex with RNA (Um-sp-Cm-Am-Am-Am-Am-Um-(2'-deoxy-2'-fluoro)G-(2'-deoxy-2'-fluoro)G-(2'-deoxy-2'-fluoro)A-(2'-deoxy-2'-fluoro)A-Gm-Gm-Um-Um-Am-Um-Am-Cm-Am-Gm-Cm-Am-Gm-Cm-Cm-Gm-[2'-O-[[2-[2-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]ethoxy]ethoxy]methyl]]A-[2'-O-[[2-[2-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]ethoxy]ethoxy]methyl]]A-[2'-O-[[2-[2-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]ethoxy]ethoxy]methyl]]A-Gm-Gm-Cm-Um-Gm-Cm) (1:1)