SP11
Based on 1 Customer Validation
SP11 is a mitochondrial fission protein 1 (Fis1) inhibitor with an IC50 of 9.4 μM. SP11 binds only to activated Fis1 by engaging Cys41. SP11 preserves mitochondrial integrity and function during oxidative stress, inhibits hydrogen peroxide-induced mitochondrial ROS production, mitochondrial fragmentation, and Drp1 mitochondrial translocation. SP11 can be used for the research of parkinson’s disease.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.91%
- CAS 番号: 2629218-24-0
- 分子式: C18H19ClN2OS
- 分子量:346.87
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保管条件:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
SP11 potently and specifically inhibits to the Cys41 residue of activated Fis1Thr34Asp, with an IC50 of 9.4 μM[1].
SP11 (250 nM; 24 h) prevents hydrogen peroxide-induced mitochondrial ROS production, fragmentation and increased Drp1 translocation to the mitochondria in HK-2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HK-2 human renal proximal tubule epithelial cells
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Concentration:250 nM (pre-incubation, then co-treated with 100 μM hydrogen peroxide)
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Incubation Time:30 min (pre-incubation); 24 h (co-treatment)
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Result:Significantly reduced hydrogen peroxide-induced Drp1 recruitment to mitochondria.
Lowered Drp1/VDAC levels to near vehicle control levels.
化学情報
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CAS 番号 2629218-24-0
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性状 Oil
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分子量 346.87
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分子式 C18H19ClN2OS
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Color Light yellow to yellow
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SMILES
CN(C(CCl)=O)CCCN1C2=CC=CC=C2SC3=C1C=CC=C3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 25 mg/mL (72.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8829 mL | 14.4146 mL | 28.8292 mL | 72.0731 mL |
| 5 mM | 0.5766 mL | 2.8829 mL | 5.7658 mL | 14.4146 mL | |
| 10 mM | 0.2883 mL | 1.4415 mL | 2.8829 mL | 7.2073 mL | |
| 15 mM | 0.1922 mL | 0.9610 mL | 1.9219 mL | 4.8049 mL | |
| 20 mM | 0.1441 mL | 0.7207 mL | 1.4415 mL | 3.6037 mL | |
| 25 mM | 0.1153 mL | 0.5766 mL | 1.1532 mL | 2.8829 mL | |
| 30 mM | 0.0961 mL | 0.4805 mL | 0.9610 mL | 2.4024 mL | |
| 40 mM | 0.0721 mL | 0.3604 mL | 0.7207 mL | 1.8018 mL | |
| 50 mM | 0.0577 mL | 0.2883 mL | 0.5766 mL | 1.4415 mL | |
| 60 mM | 0.0480 mL | 0.2402 mL | 0.4805 mL | 1.2012 mL |
SP11 関連分類
HY-172942 関連分類
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