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製品番号: HY-189759

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SQ-030

SQ-030 is a cPGES inhibitor with a human K_d of 0.315 μM. SQ-030 reduces lipid accumulation in hepatocytes. SQ-030 ameliorates hepatic dysfunction, hepatic steatosis, inflammation, and fibrosis in mice. SQ-030 alleviates hepatic dysfunction and lipid deposition in mice. SQ-030 can be used for research on metabolic dysfunction-associated steatotic liver disease (MASLD).

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 667880-05-9
分子式: C₂₁H₂₁N₃O₅
分子量:395.41

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

SQ-030 構造式

CAS 番号: 667880-05-9

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

HSP アイソフォーム固有の製品をすべて表示 :

体外実験

Lipid Metabolism

SQ-030 (PA + OA: 0.6 mM palmitate + 0.3 mM oleate; 24 h) reduces lipid accumulation in PA + OA-treated AML12 mouse hepatocytes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Innate ImmunityLipid Inflammatory MediatorsLipid Metabolism

Innate Immunity

Lipid Inflammatory Mediators

Lipid Metabolism

SQ-030 (1 mg/kg; i.p.; every other day; 4 weeks) ameliorates methionine-choline-deficient (MCD) diet-induced metabolic dysfunction-associated steatohepatitis (MASH), attenuating liver injury, steatosis, inflammation, and fibrosis without altering hepatic PGE₂-EP receptor signaling^[1].

Lipid Metabolism

SQ-030 alleviates high-fat diet (HFD)-induced hepatic dysfunction and lipid deposition^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6J (male)^[1]
Dosage:

1 mg/kg
Administration:

i.p.; every other day; for 4 weeks
Result:

Alleviated liver dysfunction (serum AST and ALT), hepatic steatosis, inflammation, and fibrosis.
Relative NAS was lower in SQ-030-treated MCD mice than in controls.
Did not change hepatic PGE2 levels or mRNA expression of the four EP receptors (Ptger1-4).

Related Protocols :

化学情報

CAS 番号 667880-05-9
分子量 395.41
分子式 C₂₁H₂₁N₃O₅
SMILES

CC1=C(C(OC)=O)C(C2=CC=C(OCC(NC3=CC=CC=C3)=O)C=C2)NC(N1)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Zhong D, et al. Cell-specific cPGES control of glucocorticoid receptor function drives MASLD progression. Cell reports. 2026 Sep 22;45(9):117901.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

生物活性
- 製品説明
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献

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SQ-030

HSP アイソフォーム固有の製品をすべて表示

生物活性

製品説明

体外実験

体内実験

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

SQ-030 関連分類

HY-189759 関連分類

Bioz

Keywords

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