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製品番号: HY-183921

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SQ 32547

SQ 32547 is a dihydropyridine calcium channel inhibitor with antihypertensive and anti-ischemic activities. SQ 32547 modulates sarcolemmal voltage-dependent calcium channels to inhibit calcium influx, and exerts direct anti-ischemic activity by suppressing myocardial contracture formation and reducing lactate dehydrogenase (LDH) release. SQ 32547 can be used in research related to hypertension, angina pectoris and neurogenic inflammation.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 135100-65-1
分子式: C₂₉H₃₂ClF₄N₃O₄S
分子量:630.09

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

SQ 32547 構造式

CAS 番号: 135100-65-1

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
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生物活性

製品説明

IC₅₀ & Target^[1]

Calcium Channel

Calcium Channel アイソフォーム固有の製品をすべて表示 :

体外実験

SQ 32547 potently inhibits KCl-induced contraction of various isolated smooth muscle preparations, with its IC₅₀ values ranging from 4.2 nM (canine saphenous vein) to 320 nM (rat vas deferens)^[2].
SQ 32547 binds irreversibly to calcium channels in vascular smooth muscle, and the drug cannot be removed by tissue elution^[2].
SQ 32547 (10-300 nM; administered before ischemia) inhibits myocardial contracture and reduces lactate dehydrogenase (LDH) leakage in a concentration-dependent manner in isolated globally ischemic rat hearts, while the degree of myocardial depression gradually increases with rising concentrations^[2].
SQ 32547 exerts a cardiodepressive effect on isolated rat hearts, and this effect cannot be washed out within 60 minutes^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

SQ 32547 (continuous intravenous infusion) alleviates ST segment elevation in canine pacing-induced stable angina model without altering systemic hemodynamics or regional myocardial blood flow^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 135100-65-1
分子量 630.09
分子式 C₂₉H₃₂ClF₄N₃O₄S
SMILES

FC(C=C1)=CC=C1CN(CC2)CCC2OC(N3[C@H](C4=C(C=CC=C4)C(F)(F)F)C(C(OC(C)C)=O)=C(NC3=S)C)=O.Cl
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Benková Z, et al. Vibrational spectra of dihydropyrimidinones. In: 7th International Electronic Conference on Synthetic Organic Chemistry (ECSOC-7); 1-30.

[2]. Grover GJ, et al. Pharmacologic Profile of the Dihydropyrimidine Calcium Channel Blockers SQ 32,547 and SQ 32,946. J Cardiovasc Pharmacol. 1995 Aug;26(2):289-294.

[3]. Woolf CJ, et al. Permanently charged sodium and calcium channel blockers as anti-inflammatory agents. WO2011006073A1, 2011.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献

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SQ 32547

Calcium Channel アイソフォーム固有の製品をすべて表示