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製品番号: HY-156088

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SSE1806

Name: SSE1806
Brand: MedChemExpress
SKU: HY-156088
Price: 94.00 USD
Availability: InStock
Rating: 5 (1 reviews)

SSE1806 is a derivative of podophyllotoxin (a natural antimitotic agent) and a microtubule/tubulin inhibitor with significant anticancer and antiproliferative activities. The GI50 of SSE1806 on cancer cell growth ranges from 1.29-21.15 μM. SSE1806 causes mitotic abnormalities and G2/M phase arrest, increases p53 expression, and inhibits colon cancer organoid growth. SSE1806 is able to overcome multidrug resistance in cell lines overexpressing MDR-1.

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CAS 番号: 3053861-26-7
分子式: C₂₁H₁₈N₂O₅
分子量:378.38

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

SSE1806 構造式

CAS 番号: 3053861-26-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
BT-549	GI₅₀	7.05 μM Compound: SSE1806	Antitumor activity against human BT-549 cells by MTS assay Antitumor activity against human BT-549 cells by MTS assay	[PMID: 37849542]
CAL-51	GI₅₀	3.3 μM Compound: SSE1806	Antiproliferative activity against human CAL-51 cells incubated for 72 hrs by SRB proliferation assay Antiproliferative activity against human CAL-51 cells incubated for 72 hrs by SRB proliferation assay	[PMID: 37849542]
HCC1954	GI₅₀	21.15 μM Compound: SSE1806	Antitumor activity against human HCC1954 cells by MTS assay Antitumor activity against human HCC1954 cells by MTS assay	[PMID: 37849542]
HCT-116	GI₅₀	2.01 μM Compound: SSE1806	Antiproliferative activity against human HCT-116 cells incubated for 72 hrs by SRB proliferation assay Antiproliferative activity against human HCT-116 cells incubated for 72 hrs by SRB proliferation assay	[PMID: 37849542]
K562	GI₅₀	17.74 μM Compound: SSE1806	Antitumor activity against human K562 cells by MTS assay Antitumor activity against human K562 cells by MTS assay	[PMID: 37849542]
KB 3-1	GI₅₀	1.29 μM Compound: SSE1806	Antitumor activity against human KB-3-1 cells by MTS assay Antitumor activity against human KB-3-1 cells by MTS assay	[PMID: 37849542]
KB 3-1	GI₅₀	1.29 μM Compound: SSE1806	Cytotoxicity against human KB-3-1 cells assessed as inhibition of cell proliferation Cytotoxicity against human KB-3-1 cells assessed as inhibition of cell proliferation	[PMID: 37849542]
KB-V1	GI₅₀	1.74 μM Compound: SSE1806	Cytotoxicity against multidrug resistant human KB-V1 cells assessed as inhibition of cell proliferation Cytotoxicity against multidrug resistant human KB-V1 cells assessed as inhibition of cell proliferation	[PMID: 37849542]
MCF7	GI₅₀	5.02 μM Compound: SSE1806	Antitumor activity against human MCF7 cells by MTS assay Antitumor activity against human MCF7 cells by MTS assay	[PMID: 37849542]
MOLM-13	GI₅₀	4.23 μM Compound: SSE1806	Antitumor activity against human MOLM-13 cells by MTS assay Antitumor activity against human MOLM-13 cells by MTS assay	[PMID: 37849542]
MV4-11	GI₅₀	9.45 μM Compound: SSE1806	Antitumor activity against human MV4-11 cells by MTS assay Antitumor activity against human MV4-11 cells by MTS assay	[PMID: 37849542]

化学情報

CAS 番号 3053861-26-7
分子量 378.38
分子式 C₂₁H₁₈N₂O₅
SMILES

O=C1CCCC2=C1C(C3=CC=CC([N+]([O-])=O)=C3)C4=CC(OCCO5)=C5C=C4N2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (273 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Firdous F, et al. Design, Synthesis, and Biological Evaluation of SSE1806, a Microtubule Destabilizer That Overcomes Multidrug Resistance[J]. ACS Medicinal Chemistry Letters, 2023...

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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