STL001
Based on 1 Customer Validation
STL001 is potent and selective FOXM1 inhibitor. STL001 induces the translocation of nuclear FOXM1 to the cytoplasm and promotes its autophagic degradation. STL001 sensitizes human cancers to a broad-spectrum of cancer therapies.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.81%
- CAS 番号: 3047493-70-6
- 分子式: C27H23N7O4
- 分子量:509.52
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Transcription Factor-Targeted Library
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Highly Selective Inhibitors Library
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Highly Selective Activators Library
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Cell Death Library
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Bioactive Compound Library Max
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MCE Bioactive Compound Library
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Bioactive Compound Library
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High-Throughput Bioactive Compound Library
HY-L205
生物活性
STL001 (1-10 μM; 24 h) causes a dose-dependent reduction of the cellular levels of FOXM1 protein[1].
STL001 (5 μM; 24 h) induces the translocation of nuclear FOXM1 to the cytoplasm and promotes its autophagic degradation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:OVCAR-8, ES-2, HCT-116, HCT-FET, FLO-1, TAM-R, HCC-1143, 22Rv1, LNCaP
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Concentration:1 μM, 5 μM, and 10 μM
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Incubation Time:24 h
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Result:Significantly reduced the cellular levels of FOXM1 protein.
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Cell Line:U2OS-C3-luc cells
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Concentration:5 μM
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Incubation Time:24 h
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Result:Resulted in reduced FOXM1 levels with increased expression of autophagy marker protein LC3.
化学情報
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CAS 番号 3047493-70-6
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性状 Solid
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分子量 509.52
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分子式 C27H23N7O4
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Color White to off-white
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SMILES
O=C(C1=CC=CO1)OC2=CC(C3=NN(C=C3)C4=NC(NC5=CC=CC=C5)=NC(N6CCOCC6)=N4)=CC=C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 5 mg/mL (9.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (277 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9626 mL | 9.8132 mL | 19.6263 mL | 49.0658 mL |
| 5 mM | 0.3925 mL | 1.9626 mL | 3.9253 mL | 9.8132 mL |
STL001 関連分類
HY-158420 関連分類
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