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United States

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製品番号: HY-125480

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T5996207

T5996207 is a MyD88 inhibitor. T5996207 inhibits LPS-induced MyD88-mediated NF-κB-driven SEAP expression. T5996207 protects mice from lethal staphylococcal enterotoxin B-induced shock. T5996207 can be used for research on acute lung injury and toxic shock.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 950003-29-9
分子式: C₂₀H₂₈N₄O₃S₂
分子量:436.59

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

T5996207 構造式

CAS 番号: 950003-29-9

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

NF-κB アイソフォーム固有の製品をすべて表示 :

体外実験

Innate ImmunityCytokines & Chemokines

Innate Immunity

T5996207 (IC₅₀ = 40-50 μM) specifically inhibits MyD88-mediated NF-κB driven SEAP activity in HEK 293T cells by directly binding to the TIR domain^[2].

Innate Immunity

Cytokines & Chemokines

T5996207 (5 million compounds) was identified as a MyD88 TIR inhibitor through in silico high-throughput screening of 5 million compounds followed by chemical similarity searching^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Bacterial InfectionCytokines & Chemokines

Bacterial Infection

Cytokines & Chemokines

T5996207 protects mice from lethal Staphylococcus enterotoxin B-induced shock by disrupting MyD88 TIR-TIR interactions^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

化学情報

CAS 番号 950003-29-9
分子量 436.59
分子式 C₂₀H₂₈N₄O₃S₂
SMILES

O=C(NCC=1SC(=CC1)S(=O)(=O)N(CC)CC)N2CCN(C=3C=CC=CC3)CC2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Zhu L, et al. Design, Synthesis, and Biological Evaluation of a MyD88-Targeted Molecular Glue d21 for the Treatment of Acute Lung Injury. Journal of medicinal chemistry. 2026 Jun 25;69(12):14722-14740. [Content Brief]

[2]. Olson MA, et al. Discovery of small molecule inhibitors of MyD88-dependent signaling pathways using a computational screen. Scientific reports. 2015 Sep 18;5:14246. [Content Brief]

[3]. Chen P. Discovery of 3g as an Orally Bioavailable, TIR Domain Selective, and Potent MyD88 Inhibitor for the Treatment of Acute Lung Injury. Journal of Medicinal Chemistry. 2025 Sep 12;68(18):19626-44. [Content Brief]

[4]. Chen L. Myeloid differentiation primary response protein 88 (MyD88): the central hub of TLR/IL-1R signaling. Journal of medicinal chemistry. 2020 Sep 15;63(22):13316-29. [Content Brief]

[5]. Olson M A, et al. Author Correction: Discovery of small molecule inhibitors of MyD88-dependent signaling pathways using a computational screen[J]. Scientific Reports, 2018, 8(1): 17074.

Calculators

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分子量分子量

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Minimum order quantity

100 mg

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