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United States

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製品番号: HY-184411

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TB-212

TB-212 is a potent, orally active anti-tuberculosis agent. TB-212 exhibits activity against both drug-susceptible and drug-resistant Mycobacterium tuberculosis strains, with favorable safety profiles. TB-212 is applicable to the research of tuberculosis.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 3104768-44-4
分子式: C₂₄H₃₀F₃N₅O₄
分子量:509.52

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

TB-212 構造式

CAS 番号: 3104768-44-4

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

TB-212 potently inhibits Mycobacterium tuberculosis H37Ra with an MIC₅₀ of 0.2 ng/mL^[1].
TB-212 (Varying concentrations; 72 h) exhibits low cytotoxicity with an IC₅₀ of 19.56 μM against HepG2 cells, IC₅₀ >30 μM against Vero cells, and IC₅₀ >50 μM against A549 cells^[1].
TB-212 (5-45 min) has moderate metabolic stability in human liver microsomes (T_1/2 = 23.71 min) and mouse liver microsomes (T_1/2 = 26.77 min)^[1].
TB-212 potently inhibits Mycobacterium tuberculosis H37Rv (MIC = 4 ng/mL) and drug-resistant clinical isolates (MIC range = 8-32 ng/mL), demonstrating efficacy against both drug-sensitive and drug-resistant strains^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

TB-212 (30-150 mg/kg; p.o.; daily; 5 days) exhibits potent in vivo antitubercular activity in BALB/c mice, with the 150 mg/kg daily oral dose^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c (female, 5-6 weeks old)^[1]
Dosage:

30 mg/kg; 150 mg/kg
Administration:

p.o.; daily; 5 days
Result:

Reduced relative light unit (RLU) values compared to the CMCNa negative control at both 30 mg/kg and 150 mg/kg doses.

化学情報

CAS 番号 3104768-44-4
分子量 509.52
分子式 C₂₄H₃₀F₃N₅O₄
SMILES

FC(F)(F)OC1=CC=C(C=C1)CN(CC2)CCC32CCN(C[C@@]4(C)CN5C(O4)=NC([N+]([O-])=O)=C5)CC3
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Wan G, et al. Design, Synthesis, and Antitubercular Activity Evaluation of Novel Nitroimidazole Derivatives. Journal of medicinal chemistry. 2026 Jun 25;69(12):14213-14235. [Content Brief]

Calculators

モル濃度計算機

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Minimum order quantity

100 mg

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