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Teclistamab

(別名: JNJ-7957; JNJ-64007957; Tecvayli)
1 Cited Publications
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Based on 1 publication(s) in Google Scholar

Teclistamab is a human bispecific antibody to BCMA and CD3 that recognizes BCMA on target cells and CD3 on T cells and induces T cell-mediated cytotoxicity leading to T cell activation and subsequent target cell lysis. Teclistamab can be used in studies of diseases related to multiple myeloma (MM).

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

  • 純度 : 99.87%
  • CAS 番号: 2119595-80-9
  • 分子量:143.64 kDa
  • 保管条件:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Teclistamab
  • Experimental Validation Results for Teclistamab
  • Experimental Validation Results for Teclistamab
  • Experimental Validation Results for Teclistamab
  • Teclistamab Chemical Structure
    Teclistamab 構造式
CAS 番号: 2119595-80-9
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
最寄りの代理店をお探しください Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG4 lambda

  • 1/16

    Immobilized Human CD3 epsilon/CD3e Protein (ECD, His Tag) can bind Teclistamab. The EC50 for this effect is 1.56 ng/mL.

  • 1/16

    Immobilized Human BCMA Protein (ECD, His Tag) can bind Teclistamab. The EC50 for this effect is 0.18 ng/mL.

  • 1/16

    Flow Cytometry analysis of K562 cells labelling BCMA (red) with Teclistamab (HY-P99392). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 lambda (HY-P99987, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Teclistamab Chemical Structure
    1/16
  • Teclistamab
  • Immobilized Human CD3 epsilon/CD3e Protein (ECD, His Tag) can bind Teclistamab. The EC50 for this effect is 1.56 ng/mL.
  • Immobilized Human BCMA Protein (ECD, His Tag) can bind Teclistamab. The EC50 for this effect is 0.18 ng/mL.
  • Flow Cytometry analysis of K562 cells labelling BCMA (red) with Teclistamab (HY-P99392). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 lambda (HY-P99987, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).