THP-NCS
THP-NCS is a bifunctional chelator bearing an isothiocyanate group, enabling radiolabeling. THP-NCS can conjugate antibody fragments for gallium isotope radiolabeling in ImmunoPET imaging. THP-NCS can conjugate biomolecules, including cyclic RGD peptides. THP-NCS can conjugate PEGylated liposomes or bone-targeting aminobisphosphonates via thiourea bonds for metal chelation pretargeting.
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- CAS 番号: 1807847-98-8
- 分子式: C66H74N10O10S2
- 分子量:1231.48
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Radionuclide-Drug Conjugates (RDCs) アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
IC50 & Target
[1]|
RDC Bifunctional Chelator |
体外実験
THP-NCS is linked via a lysine side chain to the cyclic pentapeptide c (RGDfK). The "RGD" peptide motif targets the αvβ3 integrin receptor, which is expressed on the surface of many metastatic tumor cells, as well as on inflammatory tissue and the surface of blood vessels undergoing angiogenesis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1807847-98-8
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分子量 1231.48
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分子式 C66H74N10O10S2
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SMILES
O=C1C=C(C)N(C)C(CNC(CCC(CCC(NCC2=C(C(C=C(C)N2C)=O)OCC3=CC=CC=C3)=O)(CCC(NCC4=C(C(C=C(C)N4C)=O)OCC5=CC=CC=C5)=O)NC(CCNC(NC6=CC=C(C=C6)N=C=S)=S)=O)=O)=C1OCC7=CC=CC=C7
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
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データシート (274 KB)
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SDS (252 KB)
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- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
THP-NCS 関連分類
HY-159183 関連分類
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