TMTP1
TMTP1 is a five-amino acid (NVVRQ) tumor-homing peptide. TMTP1 slows the growth of tumor cells. TMTP1 serves as a diagnostic marker for hematological malignancies and acts as an anticancer drug carrier to enhance the cellular uptake rate of nanocarriers in tumor tissues. TMTP1 is applicable to research related to hematological malignancies, lymphoma, chronic myeloid leukemia, cervical cancer, and ovarian cancer.
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- CAS 番号: 1227627-77-1
- 分子式: C25H46N10O8
- 分子量:614.69
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
TMTP1 (10-120 μM; 1 h total incubation) competitively inhibits the binding of FITC-TMTP1 to hematologic malignant cell lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
TMTP1 (35 μM; intravenous injection; single administration) can competitively block the tumor-targeting ability of TP-NLC, confirming that TMTP1 mediates the specific enrichment of this nanocarrier in cervical cancer xenografts[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Balb/c nu (female, lymphoma-bearing, tumors reached 1.5 cm3 before treatment)[1]
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Dosage:210 μg/mouse
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Administration:i.v.; twice a week; one month
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Result:Significantly inhibited tumor growth.
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Animal Model:C57BL/6 (female, 4-6 weeks old, subcutaneous xenograft model via flank injection of 2 × 105 TC-1 cells)[2]
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Dosage:35 μM
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Administration:i.v.; single dose
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Result:Reduced tumor fluorescence intensity of TP-NLC to levels comparable to free ICG and non-targeted GA/ICG-NLC groups.
化学情報
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CAS 番号 1227627-77-1
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分子量 614.69
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分子式 C25H46N10O8
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配列
Asn-Val-Val-Arg-Gln
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シーケンスの短縮
NVVRQ
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Xiao M, et al.. TMTP1, a novel tumor-homing peptide, specifically targets hematological malignancies and their metastases. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. 2011 Oct;31(5):608. [Content Brief]
[2]. Xu H, et al.. TMTP1-modified nanocarrier boosts cervical cancer immunotherapy by eliciting pyroptosis. Theranostics. 2025;15(11):5420-5439. [Content Brief]
[3]. Zhou Y, et al.. Tumor targeting peptide TMTP1 modified Antigen capture Nano-vaccine combined with chemotherapy and PD-L1 blockade effectively inhibits growth of ovarian cancer. Journal of nanobiotechnology. 2024 Aug 13;22(1):483. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
TMTP1 関連分類
HY-P11815 関連分類
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