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製品番号: HY-183624

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Trimer44NMe

Trimer44NMe is a polyamine transport inhibitor (PTI). Trimer44NMe inhibits the polyamine transport of putrescine (Put), spermidine (Spd), and spermine (Spm). Trimer44NMe can be used for research of Pancreatic ductal adenocarcinoma (PDAC).

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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CAS 番号: 1258530-99-2
分子式: C₃₆H₇₅N₉
分子量:634.04

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Trimer44NMe 構造式

CAS 番号: 1258530-99-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
L3.6pl	IC₅₀	50 μM Compound: Trimer44NMe	Cytotoxicity against human L3.6pl cells assessed as reduction in cell growth measured after 72 hrs by CellTiter96 one aqueous solution assay Cytotoxicity against human L3.6pl cells assessed as reduction in cell growth measured after 72 hrs by CellTiter96 one aqueous solution assay	[PMID: 35178189]

体外実験

Trimer44NMe inhibits the polyamine transport of putrescine (Put), spermidine (Spd), and spermine (Spm) with K_i of 17.4, 2.6, and 0.9 μM, respectively^[2].
Trimer44NMe (72 h) exhibits cytotoxicity against human pancreatic cancer cells (L3.6pl) with a maximum tolerated concentration (MTC) of 3 μM and an IC₅₀ of 50 μM^[2].
Trimer44NMe (3-10 μM, 15 min) inhibits radiolabeled polyamine uptake in L3.6pl cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 1258530-99-2
分子量 634.04
分子式 C₃₆H₇₅N₉
SMILES

CNCCCCNCCCCNCC1=CC(CNCCCCNCCCCNC)=CC(CNCCCCNCCCCNC)=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Wang M, et al. Evaluation of Polyamine Transport Inhibitors in a Drosophila Epithelial Model Suggests the Existence of Multiple Transport Systems. Med. Sci. 2017, 5, 27.

[2]. Dobrovolskaite A, et al. Development of Polyamine Lassos as Polyamine Transport Inhibitors. ACS Med Chem Lett. 2022 Jan 20;13(2):319-326. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

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