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製品番号: HY-N1117

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Tristin

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Based on 1 Customer Validation

Tristin is a PTP1B inhibitor (IC₅₀=21.2 μM) with antioxidant and antifungal activities. Tristin inhibits lipid peroxidation and NO production in LPS-stimulated macrophages, and also exhibits activity against a variety of phytopathogenic fungi. Tristin is also able to inhibit cancer cell proliferation. Tristin can be used in the research of diseases associated with phytopathogenic fungal infection, leukemia, type 2 diabetes and inflammatory responses.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 99.26%
CAS 番号: 139101-67-0
分子式: C₁₅H₁₆O₄
分子量:260.29

保管条件:

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Tristin 構造式

CAS 番号: 139101-67-0

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

NO Synthase アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>10 μM Compound: 20	Cytotoxicity against human A549 cells assessed as decrease in cell viability after 6 days by MTT assay Cytotoxicity against human A549 cells assessed as decrease in cell viability after 6 days by MTT assay	[PMID: 27310249]
HeLa	IC₅₀	>10 μM Compound: 20	Cytotoxicity against human HeLa cells assessed as decrease in cell viability after 6 days by MTT assay Cytotoxicity against human HeLa cells assessed as decrease in cell viability after 6 days by MTT assay	[PMID: 27310249]
HL-60	IC₅₀	29.06 μM Compound: 4	Anti-cancer activity against human HL-60 cells Anti-cancer activity against human HL-60 cells	[PMID: 32711292]
MCF7	IC₅₀	>10 μM Compound: 20	Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 6 days by MTT assay Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 6 days by MTT assay	[PMID: 27310249]
THP-1	IC₅₀	13.53 μM Compound: 4	Anti-cancer activity against human THP-1 cells Anti-cancer activity against human THP-1 cells	[PMID: 32711292]

体外実験

Tristin exhibits broad-spectrum antifungal activity with MIC values ranging from 96.2 to 384.6 μM^[2].
Tristin is inactive against HeLa, MCF-7, and A549 cancer cell lines with an IC₅₀ value greater than 10 μM^[2].
Tristin inhibits the proliferation of human HL-60 leukemia cells with an IC₅₀ of 29 μM and human THP-1 leukemia cells with an IC₅₀ of 13 μM^[3].
Tristin (25 μM) inhibits NO production in LPS-stimulated RAW264.7 macrophages by 27.23%^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:

Alternaria brassicicola, Phytophthora parasitica var. nicotianae, Colletotrichum capsici, Bipolaris oryzae, Diaporthe medusaea nitschke, Ceratocystis paradoxa moreau, Exserohilum turcicum, Pestallozzia theae, and Alternaria citri
Concentration:

96.2-384.6 μM
Incubation Time:

/
Result:

Exhibited broad-spectrum antifungal activity with MIC values ranging from 96.2 to 384.6 μM.

化学情報

CAS 番号 139101-67-0
性状 Solid
分子量 260.29
分子式 C₁₅H₁₆O₄
Color White to off-white
SMILES

OC1=CC(CCC2=CC=C(O)C(OC)=C2)=CC(O)=C1
Structure Classification
- Phenols
- Polyphenols
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (270 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. ONO M, et al. Antioxidative constituents from Dendrobii Herba (stems of Dendrobium spp.)[J]. Food Science and Technology International, Tokyo, 1995, 1(2): 115-120.

[2]. Zhou XM, et al. Bioactive Phenanthrene and Bibenzyl Derivatives from the Stems of Dendrobium nobile. J Nat Prod. 2016;79(7):1791-1797. [Content Brief]

[3]. He L, et al. Recent research progress on natural small molecule bibenzyls and its derivatives in Dendrobium species. Eur J Med Chem. 2020;204:112530. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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生物活性
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化学情報
純度とドキュメンテーション
参考文献

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Tristin

NO Synthase アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Tristin 関連分類

HY-N1117 関連分類