UC-773587
UC-773587 is a selective SOS1 catalytic activity inhibitor. UC-773587 binds to the catalytic site of Sos1 over HRas and ITSN (a RhoGEF) and inhibits nucleotide exchange with an IC50 value of 4.5 μM. UC-773587 mappes to the Ras switch II interaction region of the Sos1 catalytic site. UC-773587 can be used for the study of prostate cancer.
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- CAS 番号: 116679-70-0
- 分子式: C28H15O5-
- 分子量:431.42
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
化学情報
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CAS 番号 116679-70-0
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分子量 431.42
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分子式 C28H15O5-
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SMILES
OC(C=CC1=C2O3)=CC1=CC=C2C(C4=CC=CC=C4C([O-])=O)=C5C3=C6C=CC(C=C6C=C5)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Gray JL, et al. Targeting the Small GTPase Superfamily through Their Regulatory Proteins. Angew Chem Int Ed Engl. 2020 Apr 16;59(16):6342-6366. [Content Brief]
[2]. Evelyn CR, et al. Combined rational design and a high throughput screening platform for identifying chemical inhibitors of a Ras-activating enzyme. J Biol Chem. 2015 May 15;290(20):12879-98. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
UC-773587 関連分類
HY-122685 関連分類
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