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製品番号: HY-163365

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UTX-143

Name: UTX-143
Brand: MedChemExpress
SKU: HY-163365
Price: 185.00 USD
Availability: InStock
Rating: 5 (1 reviews)

UTX-143 is an inhibitor of Na+/H+ exchange protein (NHE5). UTX-143 has antitumor activity.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₁₆H₂₁N₇O₂
分子量:343.38

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

UTX-143 構造式

容量

価格（税別）

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数量

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

UTX-143 is an inhibitor of Na+/H+ exchange protein (NHE5). UTX-143 has antitumor activity^[1].

IC₅₀ & Target

NHE5^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
HT-1080	IC₅₀	15.4 μM Compound: 17; UTX-143	Cytotoxicity against human HT-1080 cells assessed as inhibition of cell growth incubated for 48 hrs by WST-8 assay Cytotoxicity against human HT-1080 cells assessed as inhibition of cell growth incubated for 48 hrs by WST-8 assay	[PMID: 38246115]
NHDF	IC₅₀	>100 μM Compound: 17; UTX-143	Cytotoxicity against HDF cells assessed as inhibition of cell growth incubated for 48 hrs by WST-8 assay Cytotoxicity against HDF cells assessed as inhibition of cell growth incubated for 48 hrs by WST-8 assay	[PMID: 38246115]
TE-1	IC₅₀	4.4 μM Compound: 17; UTX-143	Cytotoxicity against human TE-1 cells expressing NHE5 assessed as inhibition of cell growth incubated for 72 hrs by WST-8 assay Cytotoxicity against human TE-1 cells expressing NHE5 assessed as inhibition of cell growth incubated for 72 hrs by WST-8 assay	[PMID: 38246115]
TE-10	IC₅₀	49.5 μM Compound: 17; UTX-143	Cytotoxicity against human TE-10 cells expressing NHE5 assessed as inhibition of cell growth incubated for 72 hrs by WST-8 assay Cytotoxicity against human TE-10 cells expressing NHE5 assessed as inhibition of cell growth incubated for 72 hrs by WST-8 assay	[PMID: 38246115]
TE-11	IC₅₀	46.1 μM Compound: 17; UTX-143	Cytotoxicity against human TE-11 cells expressing NHE5 assessed as inhibition of cell growth incubated for 72 hrs by WST-8 assay Cytotoxicity against human TE-11 cells expressing NHE5 assessed as inhibition of cell growth incubated for 72 hrs by WST-8 assay	[PMID: 38246115]
TE-15	IC₅₀	5.1 μM Compound: 17; UTX-143	Cytotoxicity against human TE-15 cells expressing NHE5 assessed as inhibition of cell growth incubated for 72 hrs by WST-8 assay Cytotoxicity against human TE-15 cells expressing NHE5 assessed as inhibition of cell growth incubated for 72 hrs by WST-8 assay	[PMID: 38246115]
TE-5	IC₅₀	<3.1 μM Compound: 17; UTX-143	Cytotoxicity against human TE-5 cells expressing NHE5 assessed as inhibition of cell growth incubated for 72 hrs by WST-8 assay Cytotoxicity against human TE-5 cells expressing NHE5 assessed as inhibition of cell growth incubated for 72 hrs by WST-8 assay	[PMID: 38246115]
TE-6	IC₅₀	22.6 μM Compound: 17; UTX-143	Cytotoxicity against human TE-6 cells expressing NHE5 assessed as inhibition of cell growth incubated for 72 hrs by WST-8 assay Cytotoxicity against human TE-6 cells expressing NHE5 assessed as inhibition of cell growth incubated for 72 hrs by WST-8 assay	[PMID: 38246115]
TE-9	IC₅₀	24.6 μM Compound: 17; UTX-143	Cytotoxicity against human TE-9 cells expressing NHE5 assessed as inhibition of cell growth incubated for 72 hrs by WST-8 assay Cytotoxicity against human TE-9 cells expressing NHE5 assessed as inhibition of cell growth incubated for 72 hrs by WST-8 assay	[PMID: 38246115]
TMK-1	IC₅₀	25.3 μM Compound: 17; UTX-143	Cytotoxicity against human TMK-1 cells expressing HA-tagged full length human NHE5 assessed as inhibition of cell growth incubated for 72 hrs by WST-8 assay Cytotoxicity against human TMK-1 cells expressing HA-tagged full length human NHE5 assessed as inhibition of cell growth incubated for 72 hrs by WST-8 assay	[PMID: 38246115]

化学情報

分子量 343.38
分子式 C₁₆H₂₁N₇O₂
SMILES

O=C(NC(N)=N)C(N=C1C2=CC=C(C)C=C2)=C(N=C1N(CCO)C)N
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (266 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Shinohara Y, et al. Development of UTX-143, a selective sodium-hydrogen exchange subtype 5 inhibitor, using amiloride as a lead compound. Bioorg Med Chem. 2024 Feb 1;99:117603. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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