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製品番号: HY-184294

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ZH25

ZH25 is an ATR kinase inhibitor with antiproliferative activity against ATM-deficient cancer cells. ZH25 induces DNA damage, reduces G₂/M phase cell proportion, upregulates γH2AX, Cleaved-Caspase3, and Cleaved-PARP. ZH25 functions as an ATR kinase binding ligand for ATR-PROTAC degrader design. ZH25 can be used for the research of atm-deficient cancer.

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CAS 番号: 3037598-39-0
分子式: C₂₀H₂₃N₅O
分子量:349.43

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

ZH25 構造式

CAS 番号: 3037598-39-0

価格（税別）

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

ATM/ATR アイソフォーム固有の製品をすべて表示 :

体外実験

ZH25 (72 h) inhibits the proliferation of ATM-deficient LoVo cells with an IC₅₀ of 32.8 μM, but has no activity against ATM-proficient HCT116 cells or normal NCM460 cells^[1].
ZH25 (72 h) does not inhibit the proliferation of ATM-deficient NCI-H23 or GRANTA-519 cells, with IC₅₀ values >50 μM for both cell lines^[1].
ZH25 (10 μM; 72 h) induces a small increase in DNA damage in LoVo cells, and induces less DNA damage than the ATR degrader I-1 at lower concentrations^[1].
ZH25 (10 μM; 48 h) induces apoptosis in LoVo cells, and induces less apoptosis than the ATR degrader I-1 at 5 μM^[1].
ZH25 (10 μM; 48 h) reduces the proportion of LoVo cells in the G2/M phase^[1].
ZH25 (6.25-25 μM; 24 h) slightly upregulates DNA damage and apoptosis markers in LoVo cells, with weaker activity than the ATR degrader I-1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

化学情報

CAS 番号 3037598-39-0
分子量 349.43
分子式 C₂₀H₂₃N₅O
SMILES

C[C@@H]1COCCN1C2=NC(C3=CC=CC4=C3C=CN4)=NC5=C2CCNC5
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Huang L, et al. Discovery of a selective and effective CRBN-recruiting ATR degrader with strong antitumor activity. European journal of medicinal chemistry. 2026 Oct 05;315:118976. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

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100 mg

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