Zoniporide (Standard)
Zoniporide (Standard) (CP-597396 (Standard)) is the analytical standard of Zoniporide (HY-105064). This product is intended for research and analytical applications. Zoniporide (CP-597396) is a selective Na+/H+ exchanger subtype 1 (NHE1) inhibitor with cardioprotective activity, with IC50 values of 67 nM and 73 nM against rat NHE1. Zoniporide reduces intracellular Na+ and Ca2+ overload, preserves mitochondrial integrity, activates pro-survival ERK1/2 and STAT3 signaling pathways, reduces necrosis and apoptosis, and decreases neutrophil aggregation. Zoniporide is applicable to research related to myocardial ischemia-reperfusion injury and heart graft ischemia-reperfusion injury.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 241800-98-6
- 分子式: C17H16N6O
- 分子量:320.35
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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化学情報
- 純度とドキュメンテーション
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Help & FAQs
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HY-105064
ZoniporideNHE1 Inhibitor -
HY-105064D
Zoniporide hydrochloride hydrateNHE1 Inhibitor -
HY-139313
NHE3-IN-2NHE3 Inhibitor -
HY-100302
FR183998 free baseNa+/H+-Exchange Inhibitor -
HY-100325
NHE3-IN-1NHE-3 Inhibitor -
HY-100302R
FR183998 free base (Standard)Na+/H+-Exchange Inhibitor -
HY-132181
Dimethylamiloride hydrochlorideNHE Inhibitor -
HY-105064DR
Zoniporide hydrochloride hydrate (Standard)Reference Standard
Product Information
説明
アプリケーション
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
化学情報
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CAS 番号 241800-98-6
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分子量 320.35
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分子式 C17H16N6O
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SMILES
N=C(N)NC(C1=C(C2CC2)N(C3=C4C(N=CC=C4)=CC=C3)N=C1)=O
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別名
CP-597396 (Standard)
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[2]. Marala RB, et al. Zoniporide: a potent and highly selective inhibitor of human Na(+)/H(+) exchanger-1. European journal of pharmacology. 2002 Sep 06;451(1):37-41. [Content Brief]
[3]. Guzman-Perez A, et al. Discovery of zoniporide: a potent and selective sodium-hydrogen exchanger type 1 (NHE-1) inhibitor with high aqueous solubility. Bioorganic & medicinal chemistry letters. 2001 Mar 26;11(6):803-7. [Content Brief]
[5]. Watson AJ, et al. Enhanced preservation of pig cardiac allografts by combining erythropoietin with glyceryl trinitrate and zoniporide. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2013 Jul;13(7):1676-87. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Zoniporide (Standard) 関連分類
HY-105064R 関連分類
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Keywords
- Zoniporide (Standard)
- 241800-98-6
- CP-597396 (Standard)
- Reference Standards
- Na+/H+ Exchanger (NHE)
- ERK
- STAT
- Apoptosis
- rat NHE-3
- ERK1/2
- STAT3
- PS120 fibroblast cells
- myocardial ischemia-reperfusion injury
- human NHE-2
- rat NHE1
- cardiac allografts
- Na+/H+ exchanger isoform 1
- adult rat ventricular myocytes
- Inhibitor
- inhibitor
- inhibit