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Cat. No.: HY-172731

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8-Oxo-dATP lithium

8-Oxo-dATP lithium, as an oxidized purine nucleoside triphosphate, is hydrolyzed by MTH1 into monophosphates, thereby preventing errors caused by its misincorporation during DNA replication or transcription.

For research use only. We do not sell to patients.

CAS No.: 3056945-23-1
Formula: C₁₀H₁₂Li₄N₅O₁₃P₃
Molecular Weight:530.91

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

8-Oxo-dATP lithium Chemical Structure

CAS No.: 3056945-23-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All Endogenous Metabolite Isoforms :

Chemical Information

CAS No. 3056945-23-1
Molecular Weight 530.91
Formula C₁₀H₁₂Li₄N₅O₁₃P₃
SMILES

O[C@H]1C[C@H](N(C2=NC=NC(N)=C2N3)C3=O)O[C@@H]1COP(OP(OP(O[Li])(O[Li])=O)(O[Li])=O)(O[Li])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

PCNA Immunodetection Proliferation Assay
PCNA immunodetection measures proliferative activity by detecting proliferating cell nuclear antigen, a nuclear protein associated with DNA polymerase δ function and DNA replication. The assay readout is the proportion of PCNA-positive nuclei among total counted cells, but PCNA labeling is not identical to BrdU labeling because PCNA can mark late G1/early S-associated replication competence and may persist beyond active DNA synthesis depending on fixation and extraction conditions.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yasunari Sakai, et al. A molecular basis for the selective recognition of 2-hydroxy-dATP and 8-oxo-dGTP by human MTH1. J Biol Chem. 2002 Mar 8;277(10):8579-87. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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