AM841
AM841 is a high-affinity electrophilic ligand. AM841 interacts covalently with a cysteine in helix six and activates the CB1 cannabinoid receptor. AM841 reduces Forskolin (HY-15371)-stimulated cAMP accumulation. AM841 also slows gastrointestinal motility.
For research use only. We do not sell to patients.
- CAS No.: 871978-21-1
- Formula: C26H39NO3S
- Molecular Weight:445.66
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 871978-21-1
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Molecular Weight 445.66
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Formula C26H39NO3S
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SMILES
OC1=C2[C@@]3([H])[C@](CC[C@H](C3)CO)([H])C(C)(OC2=CC(C(C)(C)CCCCCCN=C=S)=C1)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Picone RP, et al. (-)-7'-Isothiocyanato-11-hydroxy-1',1'-dimethylheptylhexahydrocannabinol (AM841), a high-affinity electrophilic ligand, interacts covalently with a cysteine in helix six and activates the CB1 cannabinoid receptor. Mol Pharmacol. 2005 Dec;68(6):1623-35. [Content Brief]
[2]. Keenan CM, et al. AM841, a covalent cannabinoid ligand, powerfully slows gastrointestinal motility in normal and stressed mice in a peripherally restricted manner. Br J Pharmacol. 2015 May;172(9):2406-18. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AM841 Related Classifications
HY-149933 Related Classifications
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