APC-6860
APC-6860 is a trypsin-like serine proteases inhibitor with ki values of 0.21 and 0.44 μM for uPA and trypsin, respectively. APC-6860 has a selectivity ratio for tPA versus uPA of 80. APC-6860 has ki values of 0.1 and 0.082 μM for human and murine urokinases, respectively. APC-6860 can be used for the research of cancer.
For research use only. We do not sell to patients.
- CAS No.: 154628-42-9
- Formula: C9H7IN2S
- Molecular Weight:302.13
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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uPA 0.21 μM (Ki) |
trypsin 0.44 μM (Ki) |
tryptase 1.5 μM (Ki) |
tPA 16.8 μM (Ki) |
thrombin 20 μM (Ki) |
factor Xa 30 μM (Ki) |
human urokinases 0.1 μM (Ki) |
murine urokinases 0.082 μM (Ki) |
APC-6860 (compound 2) inhibits urokinases in MiaPaCa-2 and Lewis Lung Carcinoma cells with IC50s of 1.4 and 3.1 μM, respectively[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 154628-42-9
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Molecular Weight 302.13
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Formula C9H7IN2S
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SMILES
N=C(C1=CC2=C(I)C=CC=C2S1)N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Katz BA, et al. Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator. Chem Biol. 2000 Apr;7(4):299-312. [Content Brief]
[2]. Klinghofer V, et al. Species specificity of amidine-based urokinase inhibitors. Biochemistry. 2001 Aug 7;40(31):9125-31. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
APC-6860 Related Classifications
HY-114015 Related Classifications
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