Inosine-5'-diphosphate
Inosine-5'-diphosphate (IDP) is a decoy substrate of NM23-H2. Inosine-5'-diphosphate has a superior bond capacity on GDP-binding pocket of NM23-H2 (KD: 5.0 μM). Inosine-5'-diphosphate abrogates c-MYC transcription, induces apoptosis and G2/M cell cycle arrest by disrupting NM23-H2-Pu27-GQ interactions without affecting NM23-H2-mediated kinase properties. Inosine-5'-diphosphate has antihypoxic, antihyperthermic and antiarrhythmic activity and protects animals against the noxious effects of γ-irradiation. Inosine-5'-diphosphate can be used for cancers like Burkitt's lymphoma and cardiovascular diseases research.
For research use only. We do not sell to patients.
- CAS No.: 86-04-4
- Formula: C10H14N4O11P2
- Molecular Weight:428.19
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Inosine-5'-diphosphate (50 mg/kg; p.o.; once daily for 6 days) increases the hanging duration of the mice, while has no significant effect on the duration of swimming and running[1].
Inosine-5'-diphosphate (100 mg/kg; p.o.; 1 h befor test) has appreciable radio protective effect against γ-irradiation for mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 86-04-4
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Molecular Weight 428.19
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Formula C10H14N4O11P2
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SMILES
O=C1C2=C(N([C@H]3[C@H](O)[C@H](O)[C@@H](COP(OP(O)(O)=O)(O)=O)O3)C=N2)NC=N1
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Synonyms
IDP; Inosine-5'-diphosphoric acid
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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