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Cat. No.: HY-183730

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4E1RCat 17d

4E1RCat 17d is a derivative of the ATG5 inhibitor lead compound T1742 (HY-183807). 4E1RCat 17d shows no activity against the interactions of ATG5-ATG16L1 and ATG5-TECAIR. 4E1RCat 17d induces Autophagy inhibition.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 2841473-92-3
화학식: C₃₁H₂₄N₂O₅
분자량:504.53

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

4E1RCat 17d Chemical Structure

CAS No.: 2841473-92-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

4E1RCat 17d (Compound 17d) shows no obvious inhibitory activity against the ATG5−ATG16L1 and ATG5−TECAIR interactions in a cell-free HTRF binding assay^[1].
4E1RCat 17d (20 μM; 6 h) inhibits autophagy in COS-7 cells, reducing autophagy incidence to 20.01%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Autophagy Assay^[1]

Cell Line:

COS-7 cells
Concentration:

20 μM
Incubation Time:

6 h
Result:

Reduced autophagy incidence in COS-7 cells to 20.01%.

Chemical Information

CAS No. 2841473-92-3
분자량 504.53
화학식 C₃₁H₂₄N₂O₅
SMILES

CC(NC1=CC=CC(C2=CC=C(O2)/C=C(C3=O)\C=C(C4=CC=CC=C4)N3CC5=CC=C(C=C5)C(O)=O)=C1)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Xiang H, et al. Discovery of Small-Molecule Autophagy Inhibitors by Disrupting the Protein-Protein Interactions Involving Autophagy-Related 5. J Med Chem. 2023 Feb 23;66(4):2457-2476. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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