L-Carnosine
Based on 3 publication(s) in Google Scholar
L-Carnosine is a dipeptide composed of beta-alanine and histidine. L-Carnosine is an endogenous metabolite found in human brain, muscle and gastrointestinal tissues and is present in all vertebrates. L-Carnosine is a non-enzymatic free radical scavenger and natural antioxidant with anti-inflammatory and neuroprotective properties that can inhibit biochemical changes associated with aging.
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- Purity: 99.95%
- CAS No.: 305-84-0
- 화학식: C9H14N4O3
- 분자량:226.24
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보관:
Sealed storage, away from moisture and light.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Publications Citing Use of MedChemExpress (MCE) L-Carnosine
MoreAll Endogenous Metabolite Isoforms
More
Biological Activity
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Human Endogenous Metabolite |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
28 μM
Compound: 439224
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Substrate uptake by the Peptide Transporter 2 (PEPT2, SLC15A2) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC15A2 cells
Substrate uptake by the Peptide Transporter 2 (PEPT2, SLC15A2) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC15A2 cells
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10.5281/zenodo.7360449 |
| HEK293 | EC50 |
28 μM
Compound: 439224
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Substrate uptake by the Peptide Transporter 2 (PEPT2, SLC15A2) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC15A2 cells (PubChem AID: 1794819)
Substrate uptake by the Peptide Transporter 2 (PEPT2, SLC15A2) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC15A2 cells (PubChem AID: 1794819)
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10.5281/zenodo.7360449 |
| SH-SY5Y | EC50 |
3 μM
Compound: Carnosine
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Neuroprotective activity in human SH-SY5Y cells assessed as reduction in oxygen glucose deprivation-induced cell death incubated for 16 hrs under hypoxic condition followed by incubation for 24 hrs under normoxic condition by MTT assay
Neuroprotective activity in human SH-SY5Y cells assessed as reduction in oxygen glucose deprivation-induced cell death incubated for 16 hrs under hypoxic condition followed by incubation for 24 hrs under normoxic condition by MTT assay
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[PMID: 27420919] |
L-Carnosine is a dipeptide of the amino acids beta-alanine and histidine and has the potential to suppress many of the biochemical changes that accompany aging[1].
L-Carnosine also exhibits some antioxidant effects. The antioxidant mechanism of L-Carnosine is attributed to its chelating effect against metal ions, superoxide dismutase (SOD)-like activity, and ROS and free radicals scavenging ability[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 305-84-0
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Appearance Solid
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분자량 226.24
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화학식 C9H14N4O3
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Color White to off-white
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Structure Classification
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Sealed storage, away from moisture and light
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (3)
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Journal Impact Factor
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Most Recent
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Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
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Toxicol Appl Pharmacol
In silico and in vitro assessment of drugs potentially causing adverse effects by inhibiting CYP17A1. [Abstract]2024 May:486:116945. PMID: 38688424
용액&용해도
H2O : 83.33 mg/mL (368.33 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (442.01 mM); Clear solution; Need ultrasonic
순도&문서
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Data Sheet (276 KB)
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SDS (396 KB)
- English - EN (396 KB)
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- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
[1]. Hipkiss AR, et al. Would carnosine or a carnivorous diet help suppress aging and associated pathologies? Ann N Y Acad Sci. 2006 May;1067:369-74. [Content Brief]
[2]. Guney Y, et al. Carnosine may reduce lung injury caused by radiation therapy. Med Hypotheses. 2006;66(5):957-9. [Content Brief]
[3]. Jukić I, et al. Carnosine, small but mighty—prospect of use as functional ingredient for functional food formulation[J]. Antioxidants, 2021, 10(7): 1037. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.4201 mL | 22.1004 mL | 44.2008 mL | 110.5021 mL |
| 5 mM | 0.8840 mL | 4.4201 mL | 8.8402 mL | 22.1004 mL | |
| 10 mM | 0.4420 mL | 2.2100 mL | 4.4201 mL | 11.0502 mL | |
| 15 mM | 0.2947 mL | 1.4734 mL | 2.9467 mL | 7.3668 mL | |
| 20 mM | 0.2210 mL | 1.1050 mL | 2.2100 mL | 5.5251 mL | |
| 25 mM | 0.1768 mL | 0.8840 mL | 1.7680 mL | 4.4201 mL | |
| 30 mM | 0.1473 mL | 0.7367 mL | 1.4734 mL | 3.6834 mL | |
| 40 mM | 0.1105 mL | 0.5525 mL | 1.1050 mL | 2.7626 mL | |
| 50 mM | 0.0884 mL | 0.4420 mL | 0.8840 mL | 2.2100 mL | |
| 60 mM | 0.0737 mL | 0.3683 mL | 0.7367 mL | 1.8417 mL | |
| 80 mM | 0.0553 mL | 0.2763 mL | 0.5525 mL | 1.3813 mL | |
| 100 mM | 0.0442 mL | 0.2210 mL | 0.4420 mL | 1.1050 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
L-Carnosine Related Classifications
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