NCX 1000
Based on 1 Customer Validation
NCX 1000 is a liver-specific NO donor compound derived from ursodeoxycholic acid (UDCA).
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity : 98.91%
- CAS No.: 401519-96-8
- 화학식: C38H55NO10
- 분자량:685.84
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
More
Biological Activity
제품 설명
IC50 & Target
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Human Endogenous Metabolite |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 401519-96-8
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Appearance Solid
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분자량 685.84
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화학식 C38H55NO10
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Color White to off-white
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SMILES
C[C@H](CCC(OC1=CC=C(/C=C/C(OCCCCO[N+]([O-])=O)=O)C=C1OC)=O)[C@H]2CC[C@@]3([H])[C@]4([H])[C@@H](O)C[C@]5([H])C[C@H](O)CC[C@]5(C)[C@@]4([H])CC[C@]23C
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
용액&용해도
In Vitro:
DMSO : 100 mg/mL (145.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Fiorucci S, et al. NCX-1000, a NO-releasing derivative of ursodeoxycholic acid, selectively delivers NO to the liver and protects against development of portal hypertension. Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8897-902. Epub 2001 Jul 10. [Content Brief]
[2]. Fiorucci S, et al. NCX-1000, a nitric oxide-releasing derivative of ursodeoxycholic acid, ameliorates portal hypertension and lowers norepinephrine-induced intrahepatic resistance in the isolated and perfused rat liver. J Hepatol. 2003 Dec;39(6):932-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.4581 mL | 7.2903 mL | 14.5807 mL | 36.4516 mL |
| 5 mM | 0.2916 mL | 1.4581 mL | 2.9161 mL | 7.2903 mL | |
| 10 mM | 0.1458 mL | 0.7290 mL | 1.4581 mL | 3.6452 mL | |
| 15 mM | 0.0972 mL | 0.4860 mL | 0.9720 mL | 2.4301 mL | |
| 20 mM | 0.0729 mL | 0.3645 mL | 0.7290 mL | 1.8226 mL | |
| 25 mM | 0.0583 mL | 0.2916 mL | 0.5832 mL | 1.4581 mL | |
| 30 mM | 0.0486 mL | 0.2430 mL | 0.4860 mL | 1.2151 mL | |
| 40 mM | 0.0365 mL | 0.1823 mL | 0.3645 mL | 0.9113 mL | |
| 50 mM | 0.0292 mL | 0.1458 mL | 0.2916 mL | 0.7290 mL | |
| 60 mM | 0.0243 mL | 0.1215 mL | 0.2430 mL | 0.6075 mL | |
| 80 mM | 0.0182 mL | 0.0911 mL | 0.1823 mL | 0.4556 mL | |
| 100 mM | 0.0146 mL | 0.0729 mL | 0.1458 mL | 0.3645 mL |
NCX 1000 Related Classifications
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