AChE-IN-29
AChE-IN-29, 3-OH pyrrolidine derivative, is an cholinesterase (ChE) inhibitor. AChE-IN-29 has cholinesterase inhibitory activity for hAChE, eeAChE and eqBChE with IC50 values of 0.25 μM, 0.23 μM and 0.72 μM, respectively. AChE-IN-29 can be used for the research of Alzheimer's disease.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 3041113-91-8
- 화학식: C18H19BrN2O2
- 분자량:375.26
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- 순도&문서
- References
-
Help & FAQs
Biological Activity
IC50: 0.25 μM (hAChE); 0.23 μM (eeAChE); eqBChE (0.72 μM); 24.12 μM (in DPPH assay)[1]
AChE-IN-29 (VA10) can effectively inhibit the AChE, BChE and Aβ1-42[1].
AChE-IN-29 has Cholinesterase inhibitory activity for hAChE, eeAChE and eqBChE with IC50 values of 0.25 μM, 0.23 μM and 0.72 μM, respectively[1].
AChE-IN-29 has significant antioxidant activity with IC50 value of 24.12 μM in DPPH assay[1].
AChE-IN-29 (5 μM, 10 μM, 20 μM) can inhibit self-induced Aβ1-42 aggregation as well as hAChE-induced Aβ1-42 aggregation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:SH-SY5Y cells
-
Concentration:5, 10, and 20 μM
-
Incubation Time:72 h
-
Result:Reduced the Aβ1-42 aggregation and showed no toxic effects on tested cell line (SH-SY5Y).
AChE-IN-29 (p.o.; 10 mg/kg) recovers cell density in hippocampus region[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Male Wistar rats (200 ± 15 g)[1]
-
Dosage:2.5, 5, and 10 mg/kg
-
Administration:p.o.; once a day for seven days
-
Result:Improved cognition and memory in the scopolamine-induced cholinergic deficit.
Restoresd the neuronal cells and can inhibit neuronal toxicity in AD conditions.
Chemical Information
-
CAS No. 3041113-91-8
-
분자량 375.26
-
화학식 C18H19BrN2O2
-
SMILES
O=C(C1=CC=C(C=C1)Br)NC2=CC=CC=C2CN3CC[C@@H](C3)O
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AChE-IN-29 Related Classifications
HY-149817 Related Classifications
Powered by Bioz