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Cat. No.: HY-159116

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AChE-IN-69

AChE-IN-69 (compound 7o) is a potent AChE inhibitor with an IC₅₀ value of 1.67 µM. AChE-IN-69 has the potential for the research of Alzheimer’s disease.

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CAS No.: 2755986-33-3
화학식: C₁₆H₁₂F₃N₃OS
분자량:351.35

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

AChE-IN-69 Chemical Structure

CAS No.: 2755986-33-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

AChE-IN-69 (compound 7o) is a potent AChE inhibitor with an IC₅₀ value of 1.67 µM. AChE-IN-69 has the potential for the research of Alzheimer’s disease^[1].

IC₅₀ & Target^[1]

AChE

1.67 μM (IC₅₀)

All Cholinesterase (ChE) Isoforms :

AChE
BChE

In Vitro

AChE-IN-69 (compound 7o) binds to the active center of AChE, which hindered the substrate acetylthiocholine iodide (ATCI) from binding to the enzyme, resulting in a decrease in enzyme activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2755986-33-3
분자량 351.35
화학식 C₁₆H₁₂F₃N₃OS
SMILES

O=C1C2=C(SC(C3=CC=C(C(F)(F)F)C=C3)=N2)N=C4N1CCCC4
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zeng Y, et al. Discovery of a novel pyrido[1,2-a]thiazolo[5,4-d]pyrimidinone derivatives with excellent potency against acetylcholinesterase. Mol Divers. 2024 Jun 27. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
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AChE-IN-69

All Cholinesterase (ChE) Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

AChE-IN-69 Related Classifications

HY-159116 Related Classifications